10-Hydroxycamptothecin is a natural product derived from the bark and leaves of the Chinese tree Camptotheca acuminata. It has been extensively studied for its potential as an anticancer agent, particularly in the treatment of ovarian, lung, and colorectal cancer. 10-Hydroxycamptothecin CAS: 19685-09-7 is the chemical compound that has gained attention for its use in cancer research.
Chemical Name:
The chemical name for 10-Hydroxycamptothecin is (S)-(+)-10-Hydroxy-camptothecin.
Molecular Formula:
The molecular formula of 10-Hydroxycamptothecin is C20H16N2O5.
Formula Weight:
The formula weight of 10-Hydroxycamptothecin is 364.35 g/mol.
CAS No:
The CAS number for 10-Hydroxycamptothecin is 19685-09-7.
Top Ten Keywords and Synonyms:
Other synonyms for 10-Hydroxycamptothecin include HCPT and NSC-15295.
Health Benefits:
10-Hydroxycamptothecin has been shown to have potential as an anticancer agent, particularly in the treatment of ovarian, lung, and colorectal cancer. It works by inhibiting the activity of an enzyme called topoisomerase I, leading to DNA damage and the death of cancer cells. 10-Hydroxycamptothecin is often used in combination with other medications or as part of a chemotherapy regimen to increase its effectiveness.
Potential Effects:
The potential effects of 10-Hydroxycamptothecin include decreased tumor growth and replication. It works by binding to the topoisomerase I enzyme, preventing it from functioning properly during DNA replication. This ultimately leads to the death of cancer cells.
Product Mechanism:
10-Hydroxycamptothecin works by binding to the topoisomerase I enzyme, preventing it from functioning properly during DNA replication. This leads to the formation of abnormal DNA structures within the cancer cells, causing them to stop dividing and eventually die off.
Safety:
10-Hydroxycamptothecin should only be used under the supervision of a qualified healthcare provider. It can cause serious side effects, including decreased production of blood cells, liver damage, and allergic reactions. Patients who are allergic to 10-Hydroxycamptothecin or any of its ingredients should not use this medication. It is important to tell your healthcare provider about all medications you are taking before starting treatment with 10-Hydroxycamptothecin.
Side Effects:
Common side effects of 10-Hydroxycamptothecin include fatigue, nausea, vomiting, diarrhea, hair loss, and muscle pain. Less common side effects may include allergic reactions, including rash, hives, and difficulty breathing. Liver damage can also occur, which may cause yellowing of the skin and eyes.
Dosing Information:
The dose of 10-Hydroxycamptothecin will depend on the patient's age, weight, and overall health. The medication is usually given as an injection into the vein. Treatment may continue for several weeks or months.
Conclusion:
10-Hydroxycamptothecin is a natural product derived from the Chinese tree Camptotheca acuminata, and it has gained attention for its potential use as an anticancer agent, particularly in the treatment of ovarian, lung, and colorectal cancer. It works by inhibiting the activity of the topoisomerase I enzyme, leading to DNA damage and the death of cancer cells. While it can be effective in treating cancer, it can also cause serious side effects and should only be used under the supervision of a qualified healthcare provider
