3-Aminobenzamide is a chemical compound that has been widely used in medical research as a tool for studying DNA repair, apoptosis, and cellular signaling pathways. It is a potent inhibitor of poly(ADP-ribose) polymerase (PARP) enzymes, which are involved in DNA repair mechanisms. 3-Aminobenzamide has been studied extensively in preclinical and clinical trials and has shown potential in various therapeutic applications. In this article, we will discuss the chemical name, molecular formula, formula weight, and CAS number of 3-Aminobenzamide. We will also explore the health benefits, mechanism of action, potential effects, safety, side effects, and dosing information for this versatile research compound.
Chemical Name:
The chemical name of 3-Aminobenzamide is 3-Aminobenzamide.
Molecular Formula:
The molecular formula of 3-Aminobenzamide is C7H8N2O.
Formula Weight:
The formula weight of 3-Aminobenzamide is 136.15.
CAS No:
The CAS number for 3-Aminobenzamide is 3544-24-9.
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Health Benefits of 3-Aminobenzamide:
3-Aminobenzamide has shown potential therapeutic benefits in various preclinical and clinical studies. It has been found to inhibit PARP enzymes that are involved in the DNA repair mechanisms. Inhibition of PARP leads to increased DNA damage and apoptosis of cancer cells, which may contribute to the anti-tumor effects of 3-Aminobenzamide. Moreover, 3-Aminobenzamide has been found to have anti-inflammatory activity, which can potentially alleviate inflammatory conditions. Additionally, 3-Aminobenzamide has been found to sensitize cancer cells to chemotherapy agents, which can improve the efficacy of chemotherapy in cancer treatment.
Potential Effects of 3-Aminobenzamide:
Several preclinical and clinical studies have demonstrated the potential therapeutic effects of 3-Aminobenzamide. In preclinical studies, 3-Aminobenzamide has been found to inhibit PARP activity, induce apoptosis, and sensitize cancer cells to chemotherapy agents. In clinical studies, 3-Aminobenzamide has been found to be well-tolerated and has shown promising results in cancer treatment. It has shown anti-tumor effects in various types of cancer, including breast, ovarian, and colorectal cancer. Moreover, 3-Aminobenzamide has been found to alleviate inflammatory conditions, such as sepsis and liver inflammation.
Product Mechanism:
3-Aminobenzamide is a potent inhibitor of PARP enzymes that are involved in the DNA repair mechanisms. PARP enzymes are activated in response to DNA damage and catalyze the transfer of ADP-ribose units from NAD+ to target proteins, including PARP itself, to facilitate DNA repair mechanisms. Inhibition of PARP by 3-Aminobenzamide leads to the accumulation of DNA damage and the induction of apoptosis in cancer cells. Moreover, inhibition of PARP by 3-Aminobenzamide has been found to sensitize cancer cells to chemotherapy agents, which can improve the efficacy of chemotherapy in cancer treatment.
Safety:
3-Aminobenzamide has been found to be safe and well-tolerated in preclinical and clinical studies. However, like any other medication, 3-Aminobenzamide can have potential side effects, which may include gastrointestinal disturbances, skin rash, and hematologic toxicities such as thrombocytopenia and leukopenia. Therefore, careful monitoring of hematologic parameters may be required during treatment with 3-Aminobenzamide.
Side Effects:
The potential side effects of 3-Aminobenzamide may include gastrointestinal disturbances, skin rash, and hematologic toxicities such as thrombocytopenia and leukopenia. Therefore, careful monitoring of hematologic parameters may be required during treatment with 3-Aminobenzamide.
Dosing Information:
The optimal dosing of 3-Aminobenzamide has not yet been established. However, in preclinical studies, 3-Aminobenzamide has been administered intraperitoneally at doses ranging from 25 to 1000 mg/kg/day for up to 72 hours. In clinical trials, 3-Aminobenzamide has been administered orally or intravenously at doses ranging from 10 to 60 mg/kg/day. The dosing schedules and regimens for 3-Aminobenzamide may vary depending on the type of cancer being treated, the stage of the disease, and the patient's overall health and medical history.
Conclusion:
3-Aminobenzamide is a versatile research compound that has shown potential in various therapeutic applications. It is a potent inhibitor of PARP enzymes, which are involved in DNA repair mechanisms. 3-Aminobenzamide has been found to have anti-tumor effects, anti-inflammatory activity, and chemosensitization effects. Moreover, 3-Aminobenzamide has been found to be safe and well-tolerated in preclinical and clinical studies. However, like any other medication, 3-Aminobenzamide can have potential side effects and careful monitoring of hematologic parameters may be required during treatment. Further studies and clinical trials are needed to establish the safety and efficacy of 3-Aminobenzamide in various therapeutic applications
