3-Methyladenine (3-MA) is a natural compound that has been found to have various health benefits. It is a potent inhibitor of the enzyme PI3K, which is involved in several cellular pathways, including autophagy and apoptosis. In this article, we will explore the chemical properties of 3-MA, its potential health benefits, side effects, and dosing information.
Chemical name:
The chemical name of 3-Methyladenine is 3-Methyl-1H-purin-6-amine.
Molecular formula:
The molecular formula of 3-Methyladenine is C6H7N5.
Formula weight:
The formula weight of 3-Methyladenine is 149.15 g/mol.
CAS No:
The CAS number of 3-Methyladenine is 5142-23-4.
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Synonyms:
Health benefits of 3-Methyladenine:
Cancer treatment: 3-Methyladenine has been shown to inhibit the growth of various types of cancer cells, including breast, lung, and colon cancer cells. It does so by inducing apoptosis and inhibiting autophagy, two cellular processes that are involved in cancer cell survival and proliferation.
Neuroprotection: 3-Methyladenine can protect neurons from oxidative stress and mitochondrial dysfunction, making it a potential treatment option for neurodegenerative diseases such as Alzheimer's and Parkinson's disease.
Anti-inflammatory: 3-Methyladenine has been shown to reduce inflammation in animal studies, making it a potential treatment option for inflammatory conditions such as arthritis and asthma.
DNA repair: 3-Methyladenine can stimulate DNA repair mechanisms, making it a potential treatment option for conditions caused by DNA damage, such as aging and cancer.
Potential effects:
Autophagy inhibition: 3-Methyladenine inhibits autophagy, a cellular process that removes damaged or dysfunctional components, which can lead to the accumulation of toxic proteins and organelles.
Apoptosis induction: 3-Methyladenine induces apoptosis, a form of programmed cell death that eliminates damaged or abnormal cells.
PI3K inhibition: 3-Methyladenine is a potent inhibitor of the enzyme PI3K, which is involved in several cellular pathways, including autophagy and apoptosis.
Mitochondrial dysfunction: High doses of 3-Methyladenine can cause mitochondrial dysfunction and oxidative stress, leading to cell death.
Product mechanism:
3-Methyladenine works by inhibiting autophagy and inducing apoptosis in cells. It blocks the activity of the enzyme PI3K, which is involved in several cellular pathways, including autophagy and apoptosis. By inhibiting PI3K, 3-Methyladenine can inhibit autophagy and induce apoptosis, leading to the elimination of damaged or abnormal cells.
It also protects neurons from oxidative stress and mitochondrial dysfunction, which can contribute to neurodegenerative diseases. By stimulating DNA repair mechanisms, 3-Methyladenine can repair damaged DNA and prevent the development of cancer and other age-related diseases.
Safety:
3-Methyladenine is generally safe when used in recommended doses. However, high doses may cause mitochondrial dysfunction and oxidative stress, leading to cell death. Individuals with liver or kidney disease should avoid using 3-Methyladenine.
Side effects:
3-Methyladenine may cause gastrointestinal side effects, such as nausea, vomiting, and diarrhea, in some individuals. Rarely, it may cause mitochondrial dysfunction and oxidative stress when used in high doses or for long periods.
Dosing information:
There is no established dose of 3-Methyladenine for specific health conditions. However, doses ranging from 10 µM to 10 mM have been used in various cellular and animal studies. It is best to consult a healthcare provider before using 3-Methyladenine for any health condition.
Conclusion:
3-Methyladenine is a natural compound that has shown promise for treating various health conditions, including cancer, neurodegenerative diseases, and inflammation. Its ability to inhibit autophagy and induce apoptosis makes it a potential anti-cancer agent. Additionally, its ability to protect neurons from oxidative stress and mitochondrial dysfunction makes it a potential treatment option
