ABT-737, also known as ABT737, is a small molecule inhibitor that acts against B-cell lymphoma 2 (Bcl-2) family proteins, used primarily in the pharmaceutical industry for cancer treatment. It is a synthetic substance consisting of a small, heterocyclic, aryl-2-pyrazole that targets Bcl-2 family proteins. The chemical name for ABT-737 is 4-((4-(4-((2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl)methyl)piperazin-1-yl)phenyl)amino)-1H-pyrazole-3-carboxamide. Its molecular formula is C42H45ClN6O3, and its molar mass is 737.31 g/mol. Its CAS No is 852808-04-9.
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Some synonyms of ABT-737 include ABT 737, ABT-737, and 852808-04-9.
Health Benefits of ABT-737
ABT-737 is primarily used for the treatment of various forms of cancer, including lymphomas, melonoma, and leukemias. The product has been found to be effective in targeting Bcl-2 family proteins to induce apoptosis or programmed cell death in cancer cells without affecting healthy cells.
Potential Effects of ABT-737
ABT-737 has been found to be effective in treating various types of cancer by inducing apoptosis in cancer cells. Additionally, it has been shown to be effective in overcoming drug resistance in cancer cells when used in combination with other agents.
Product Mechanism of ABT-737
ABT-737 works by targeting anti-apoptotic Bcl-2 family proteins, which are responsible for allowing cancer cells to continue to grow and thrive. The protein family includes Bcl-2, Bcl-xL, and Bcl-w. ABT-737 binds to and inhibits the action of these proteins, which triggers apoptosis in cancer cells.
Safety of ABT-737
The safety of ABT-737 is still being studied to determine the appropriate dosage and risks associated with the treatment. More information on effects on pregnancy, fetus and nursing babies needs to be confirmed with scientific research
Side Effects of ABT-737
The side effects of ABT-737 are still being studied, and more research is needed to determine the safety of the product in humans. Some potential side effects of the product include thrombocytopenia, anemia, neutropenia, fatigue, and gastrointestinal disturbances.
Dosing Information of ABT-737
The dosing information for ABT-737 varies depending on the individual and the condition being treated. A qualified healthcare professional should determine the appropriate dose of ABT-737. It is generally administered orally in a capsule form.
Conclusion
ABT-737 is a valuable product for cancer treatment that targets Bcl-2 family proteins and triggers apoptosis in cancer cells. However, more research is needed to determine the appropriate dosage and potential side effects of the treatment. The small molecule inhibitor has demonstrated promising results in fighting drug resistance in cancer cells and increasing the efficacy of concurrent treatments. As with any new treatment or product, patients should consult with a qualified health professional before use. The research progress on ABT-737 will further establish its place as a valuable clinical treatment tool for various forms of cancer in the pharmaceutical industry.
