AR-42, also known as OSU-HDAC42 or HDAC-42, is a small molecule inhibitor of histone deacetylase (HDAC), which is an enzyme involved in the regulation of gene expression through chromatin modification. It was first discovered in 2009 and has since been studied for its potential as a treatment for various types of cancer.
Chemical name:
The chemical name for AR-42 is (E)-N-hydroxy-4-[[(2-methylphenyl)amino]methylene]-benzamide.
Molecular formula:
The molecular formula of AR-42 is C16H16N2O2.
Formula weight:
The formula weight of AR-42 is 268.31 g/mol.
CAS No:
The CAS number of AR-42 is 935881-37-1.
Top ten keywords from Google and Synonyms:
Synonyms:
Health benefits of this product:
AR-42 has been primarily developed for the treatment of cancer. As an HDAC inhibitor, it is thought to regulate gene expression by promoting acetylation of histones, leading to changes in chromatin structure and gene transcription.
Potential effects:
Some potential effects of AR-42 include:
Product mechanism:
AR-42 works by inhibiting HDAC, which is an enzyme involved in the regulation of gene expression through chromatin modification. By inhibiting HDAC, AR-42 can promote acetylation of histones, leading to changes in chromatin structure and gene transcription.
Safety:
AR-42 has been tested in preclinical and clinical studies for its safety profile. The drug has been found to have acceptable toxicity and has not shown any significant adverse effects on normal tissues or organs. However, as with any medication, there are some risks associated with its use. Patients should inform their healthcare provider of any pre-existing medical conditions or medications they are taking before starting treatment with AR-42.
Side effects:
AR-42 can cause several side effects in some patients. These can include:
Dosing information:
The optimal dosing regimen of AR-42 has not yet been established and further research is needed to determine the most effective dose. In preclinical studies, doses ranged from 10 to 50 mg/kg. In clinical trials, doses ranged from 20 to 120 mg once daily. The drug is typically administered orally.
Conclusion:
AR-42 is a small molecule inhibitor of HDAC that has shown potential as a treatment for various types of cancer. By inhibiting HDAC, AR-42 may regulate gene expression by promoting acetylation of histones, leading to changes in chromatin structure and gene transcription. The drug has undergone several preclinical and clinical trials and has been found to have an acceptable safety profile. However, as with any medication, there are some risks associated with its use. Further research is needed to determine the optimal dosing regimen and efficacy of AR-42 in treating various types of cancer
