Azelnidipine is a third-generation dihydropyridine calcium channel blocker that is used to treat hypertension. It was initially developed by Japanese pharmaceutical company Chugai in the 1990s and has since been marketed under various brand names worldwide.
The chemical name for Azelnidipine is (3R)-3-(1-Benzyl-1H-tetrazol-5-yl)-5-isopropyl 2-amino-6-methyl-4-(3-nitrophenyl) -1,4-dihydropyridine-3,5-dicarboxylate.
The molecular formula of Azelnidipine is C33H34N6O6.
The formula weight of Azelnidipine is 602.67 g/mol.
The CAS number of Azelnidipine is 123524-52-7.
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Health benefits of this product:
Azelnidipine is primarily used to treat hypertension or high blood pressure. It is a calcium channel blocker, which means it works by preventing the entry of calcium into the smooth muscle of blood vessels, resulting in relaxation of these muscles and dilation of blood vessels. This leads to a decrease in blood pressure and an improvement in blood flow throughout the body.
Some potential effects of Azelnidipine include:
- Decreased blood pressure
- Improved blood flow to organs and tissues
- Reduced risk of heart attack and stroke
- Improved symptoms of angina (chest pain)
- Improved renal function in patients with chronic kidney disease
Azelnidipine works by blocking L-type calcium channels in the smooth muscle of blood vessels. This leads to a decrease in the influx of calcium ions, which inhibits the contraction of the smooth muscle and causes vasodilation. By dilating blood vessels, Azelnidipine reduces peripheral resistance and decreases blood pressure.
Azelnidipine is generally safe when used as prescribed. However, like any medication, there are some risks associated with its use. Some common side effects include headache, dizziness, flushing, nausea, and ankle swelling. More serious side effects are rare and may include allergic reactions, liver dysfunction, and heart failure. Before taking Azelnidipine, patients should inform their healthcare provider of any pre-existing medical conditions or medications they are taking.
Azelnidipine can cause several side effects in some patients. These can include:
- Ankle swelling
- Abdominal pain
The recommended starting dose of Azelnidipine is 8 mg once daily. The dose may be increased to 16 mg once daily after two weeks if the response is inadequate. The maximum recommended dose is 32 mg once daily. Azelnidipine should be taken at the same time each day, with or without food.
Azelnidipine is a third-generation calcium channel blocker that is primarily used to treat hypertension. By inhibiting calcium influx into smooth muscle cells, it causes vasodilation and reduces peripheral resistance, leading to decreased blood pressure and improved blood flow. Azelnidipine is generally safe when used as prescribed, but can cause side effects in some patients. It is important for patients to inform their healthcare provider of any pre-existing medical conditions or medications they are taking before starting treatment with Azelnidipine.