Baicalein is a flavone compound, also known as 5,6,7-trihydroxyflavone. It has a molecular formula of C15H10O5, a molecular weight of 270.24 g/mol, and its CAS number is 491-67-8.
Top Ten Keywords and Synonyms:
Health Benefits of Baicalein: Baicalein has been used in traditional Chinese medicine for its anti-inflammatory, antioxidant, and antimicrobial properties. In recent years, studies have investigated the potential therapeutic effects of baicalein in various diseases.
Anti-inflammatory Effects: Studies have shown that baicalein inhibits the production of pro-inflammatory cytokines, such as interleukin-1 beta (IL-1β), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α). Baicalein also suppresses the activation of nuclear factor-kappa B (NF-κB), a transcription factor that plays a key role in inflammation. These effects make baicalein a potential treatment for inflammatory diseases such as rheumatoid arthritis, inflammatory bowel disease, and asthma.
Antioxidant Activity: Baicalein has been found to have potent antioxidant properties. It scavenges free radicals and protects cells from oxidative stress, which is implicated in the development of many chronic diseases, including cancer, neurodegenerative diseases, and cardiovascular diseases.
Neuroprotective Effects: Baicalein has been shown to ameliorate cognitive impairment induced by aging, stress, and neurotoxicity in animal models. Its neuroprotective effects are thought to be mediated by its ability to reduce oxidative stress, inflammation, and apoptosis in the brain.
Antimicrobial Activity: Baicalein has been reported to have antibacterial, antifungal, and antiviral activities. It inhibits the growth of various bacteria, including Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa. Baicalein also inhibits the replication of herpes simplex virus, human immunodeficiency virus (HIV), and hepatitis B virus (HBV).
Anticancer Activity: Baicalein has been reported to inhibit the growth and proliferation of various cancer cells, including breast cancer, lung cancer, colon cancer, and leukemia cells. Its anticancer effects are thought to be mediated by its ability to induce cell cycle arrest, apoptosis, and inhibit angiogenesis.
Product Mechanism: Baicalein exerts its therapeutic effects through multiple mechanisms. It modulates various signaling pathways involved in inflammation, oxidative stress, and apoptosis. Baicalein inhibits the activation of NF-κB, a transcription factor that regulates the expression of genes involved in inflammation and immune responses. It also activates Nrf2 (nuclear factor erythroid 2-related factor 2), a transcription factor that upregulates the expression of antioxidant and cytoprotective genes. Baicalein also modulates the activity of enzymes involved in phase I and II detoxification, which helps to eliminate toxins and carcinogens from the body.
Safety and Side Effects: Baicalein is generally considered safe when used as directed. However, high doses or prolonged use may cause gastrointestinal upset, headache, dizziness, and allergic reactions. Baicalein may also interact with certain medications, such as blood thinners and sedatives.
Dosing Information: There is no standard dosing for baicalein because it depends on the condition being treated. However, typical doses range from 100 to 500 mg per day, taken orally.
In Conclusion: Baicalein is a natural compound with promising therapeutic potential. Its anti-inflammatory, antioxidant, neuroprotective, antimicrobial, and anticancer properties make it a valuable candidate for the development of new drugs. However, more research is needed to determine its efficacy, safety, and optimal dosing in humans. As with any dietary supplement, it is important to consult a healthcare professional before taking baicalein.
