Baicalin is a flavone glycoside compound, also known as scutellarein-7-O-glucuronide or 5,6-dihydroxy-4-oxo-2-phenyl-4H-chromen-7-yl β-D-glucopyranosiduronic acid. Its molecular formula is C21H18O11, and it has a molecular weight of 446.36 g/mol. The CAS number for baicalin is 21967-41-9.
Top Ten Keywords and Synonyms:
- Baicalin extract
- Scutellaria baicalensis extract
- Anti-inflammatory properties
- Antioxidant activity
- Neuroprotective effects
- Hepatoprotective effects
- Anticancer activity
- Baikal skullcap extract
- 5,6-dihydroxy-4-oxo-2-phenyl-chromen-7-yl beta-D-glucopyranosiduronic acid
Health Benefits of Baicalin: Baicalin extract has been used in traditional medicine for its anti-inflammatory, antioxidant, and hepatoprotective properties. In recent years, studies have investigated the potential therapeutic effects of baicalin in various diseases.
Anti-inflammatory Effects: Studies have shown that baicalin inhibits the production of inflammatory cytokines, such as interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), and prostaglandin E2 (PGE2). Baicalin also suppresses the activation of nuclear factor-kappa B (NF-κB), a transcription factor that plays a key role in inflammation. These effects make baicalin a potential treatment for inflammatory diseases such as rheumatoid arthritis, inflammatory bowel disease, and asthma.
Antioxidant Activity: Baicalin has been found to have potent antioxidant properties. It scavenges free radicals and protects cells from oxidative stress, which is implicated in the development of many chronic diseases, including cancer, neurodegenerative diseases, and cardiovascular diseases.
Neuroprotective Effects: Baicalin has been shown to ameliorate cognitive impairment induced by aging, stress, and neurotoxicity in animal models. Its neuroprotective effects are thought to be mediated by its ability to reduce oxidative stress, inflammation, and apoptosis in the brain.
Hepatoprotective Effects: Baicalin has been shown to protect the liver from injury caused by various toxins and drugs. Its hepatoprotective effects are attributed to its antioxidative, anti-inflammatory, and anti-apoptotic properties.
Anticancer Activity: Baicalin has been reported to inhibit the growth and proliferation of various cancer cells, including breast cancer, lung cancer, colon cancer, and leukemia cells. Its anticancer effects are thought to be mediated by its ability to induce cell cycle arrest, apoptosis, and inhibit angiogenesis.
Product Mechanism: Baicalin exerts its therapeutic effects through multiple mechanisms. It modulates various signaling pathways involved in inflammation, oxidative stress, and apoptosis. Baicalin inhibits the activation of NF-κB, a transcription factor that regulates the expression of genes involved in inflammation and immune responses. It also activates Nrf2 (nuclear factor erythroid 2-related factor 2), a transcription factor that upregulates the expression of antioxidant and cytoprotective genes. Baicalin also modulates the activity of enzymes involved in phase I and II detoxification, which helps to eliminate toxins and carcinogens from the body.
Safety and Side Effects: Baicalin is generally considered safe when used as directed. However, high doses or prolonged use may cause gastrointestinal upset, headache, dizziness, and allergic reactions. Baicalin may also interact with certain medications, such as blood thinners and sedatives.
Dosing Information: There is no standard dosing for baicalin because it depends on the condition being treated. However, typical doses range from 100 to 500 mg per day, taken orally.
In Conclusion: Baicalin is a natural compound with promising therapeutic potential. Its anti-inflammatory, antioxidant, neuroprotective, hepatoprotective, and anticancer properties make it a valuable candidate for the development of new drugs. However, more research is needed to determine its efficacy, safety, and optimal dosing in humans. As with any dietary supplement, it is important to consult a healthcare professional before taking baicalin