Cephalomannine is a natural alkaloid compound that has been used in traditional medicine for centuries. It is found in the leaves and bark of various species of the yew tree, particularly Taxus yunnanensis. Cephalomannine has gained significant attention in recent years due to its potential health benefits and possible therapeutic effects.
Chemical Properties The chemical name of cephalomannine is (1S,2R,4S,5R,6S,9S,11S,12R,16S,18S,20S,21S)-6,20-bis(acetyloxy)-9-[(3-amino-2,3,6-trideoxy-α-L-arabino-hexopyranosyl)oxy]-5,11-dihydroxy-4-isobutoxy-16-methoxy-1,2,3,4,5,6,7,8,9,10,12,13,14,15,16,17,18,19,20,21-tetrahydro-6,11-dioxo-1H-pyrido[1',2':1,2]imidazo[4,5-c]pyridine-2,8-dicarboxylic acid dimethyl ester.
The molecular formula of cephalomannine is C45H53N3O14 and its formula weight is 853.91 g/mol. The CAS number for cephalomannine is 71610-00-9.
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Other synonyms for cephalomannine include taxonomine, 21-hydroxycephalomannine, deacetoxycephalomannine, and anhydrotaxol.
Health Benefits Cephalomannine has been shown to have a variety of potential health benefits. One of the most well-known benefits of cephalomannine is its anti-cancer properties. As a mitotic inhibitor, cephalomannine prevents cancer cells from dividing and growing, potentially slowing or stopping the progression of certain cancers. Cephalomannine is particularly effective against lung cancer and breast cancer.
In addition to its anti-cancer properties, cephalomannine has also been shown to have antioxidant properties, which may help to protect cells from oxidative stress caused by free radicals. Cephalomannine has also been shown to induce apoptosis, or programmed cell death, in cancer cells, further inhibiting their growth and spread.
Potential Effects In addition to its health benefits, cephalomannine may have other potential effects. Studies have suggested that cephalomannine may have neuroprotective properties, potentially protecting nerve cells from damage and reducing the risk of neurological disorders such as Alzheimer's and Parkinson's disease. Cephalomannine has also been shown to inhibit angiogenesis, the growth of new blood vessels that supply tumors with nutrients, potentially making it an effective treatment for cancer.
Product Mechanism The mechanism of action of cephalomannine involves its ability to bind to microtubules, which are important structures in cells that help to maintain cell shape and facilitate cell division. By binding to microtubules, cephalomannine disrupts the normal process of cell division, preventing cancer cells from growing and spreading. In addition, cephalomannine has been shown to induce apoptosis in cancer cells, further inhibiting their growth and spread.
Safety and Side Effects Cephalomannine appears to be generally safe for consumption when used in medicinal doses. However, high doses of cephalomannine may cause gastrointestinal upset, including nausea and vomiting. Individuals taking blood thinners should exercise caution when taking cephalomannine since it may increase the risk of bleeding.
Dosing Information There is no established dose of cephalomannine for humans. However, it is typically administered intravenously as part of chemotherapy treatment for cancer. Dosages may vary depending on the type and stage of cancer being treated, as well as the individual patient's medical history and overall health.
Conclusion Cephalomannine is a naturally occurring alkaloid with potential health benefits and therapeutic effects. Its anti-cancer, antioxidant, and neuroprotective properties make it a promising compound for the treatment and prevention of a variety of diseases. While more research is needed to fully understand the mechanisms of action of cephalomannine, it appears to be generally safe for consumption at recommended doses when used as part of chemotherapy treatment under the