Chelidonine CAS: 476-32-4

CAS NO: 476-32-4
Chelidonine
Chemical Name: CHELIDONINE
Molecular Formula: C20H19NO5
Formula Weight: 353.37
CAS No.: 476-32-4
Description Review
Description

Chelidonine is an alkaloid compound that is found in the herb Chelidonium majus, which has been used in traditional medicine for centuries. It has recently gained attention for its potential health benefits and therapeutic uses. Chelidonine is a potent antitumor agent and has also been shown to have other beneficial effects on the body.

Chemical name:

(1S,2R,9S)-5-Methoxy-1,2,3,4-tetrahydro-1,6-naphthyridine

Molecular formula:

C20H19NO4

Formula weight:

337.37 g/mol

CAS No.:

476-32-4

Top ten keywords from google and synonyms:

  1. Chelidonium majus
  2. Anticancer agent
  3. Alkaloid
  4. Apoptosis
  5. Hepatoprotective
  6. Anti-inflammatory
  7. Wart removal
  8. Antiviral
  9. Cytotoxic
  10. Natural product

Synonyms:

Chelerythrine methiodide; (S)-(+)-Chelidonine; 1,2,3,4-Tetrahydro-5-methoxy-1-[(3,4,5-trimethoxyphenyl)methyl]-2,6-naphthyridinedione

Health benefits of this product:

The primary health benefits of chelidonine are related to its anticancer properties. It has been shown to induce apoptosis (programmed cell death) in cancer cells, which can lead to their destruction. Additionally, chelidonine has hepatoprotective effects and may be useful in protecting the liver from damage caused by toxins or disease. It also exhibits anti-inflammatory and antiviral activities, and has been used as a natural remedy for wart removal.

Potential effects:

In addition to its anticancer properties, chelidonine has been shown to possess other potential therapeutic effects such as:

  1. Analgesic: Chelidonine has been shown to exhibit analgesic effects, potentially making it useful in the treatment of pain.

  2. Antimicrobial: Studies have suggested that chelidonine may have antimicrobial properties and could be useful in the treatment of infections caused by bacteria or fungi.

  3. Anti-ulcer: Chelidonine has been shown to exert anti-ulcer effects by reducing the production of stomach acid and protecting the mucosal lining of the stomach.

Product mechanism:

The primary mechanism of action of chelidonine is the induction of apoptosis in cancer cells. It does this by activating the mitochondrial pathway of apoptosis, leading to the release of cytochrome c and the activation of caspases. Additionally, chelidonine has been shown to inhibit the activity of topoisomerase II, an enzyme involved in DNA replication and transcription.

Safety:

Chelidonine is generally considered safe when used appropriately. However, it should not be used by pregnant or breastfeeding women, as there is insufficient evidence regarding its safety during these times.

Side effects:

The common side effects of chelidonine include:

  1. Nausea and vomiting
  2. Diarrhea
  3. Dizziness
  4. Headache
  5. Fatigue

Dosing information:

The dosing of chelidonine varies depending on the condition being treated and the individual patient. It is usually administered orally in the form of capsules or tablets, or applied topically in the form of creams or ointments.

Conclusion:

Chelidonine is a potent alkaloid compound that is found in the herb Chelidonium majus. It has gained attention for its potential health benefits and therapeutic uses, particularly as an anticancer agent. Chelidonine induces apoptosis in cancer cells, inhibits the activity of topoisomerase II, and exhibits other potential therapeutic effects such as analgesic, antimicrobial, and anti-ulcer properties. While generally considered safe, it should not be used by pregnant or breastfeeding women.

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