Coluracetam CAS: 135463-81-9

CAS NO: 135463-81-9
name :  Coluracetam
Chemical Name: N-(2,3-dimethyl-5,6,7,8-tetrahydrofuro[2,3-b]quinolin-4-yl)-2-(2-oxopyrrolidin-1-yl)acetamide
Molecular Formula: C19H23N3O3
Formula Weight: 341.41 g/mol
CAS No: 135463-81-9
Description Review

Coluracetam is a nootropic compound that is believed to enhance cognitive function and improve memory. It was first developed in Japan in the 1990s and has since gained popularity as a dietary supplement.

Chemical Name:

The chemical name for Coluracetam is N-(2,3-dimethyl-5,6,7,8-tetrahydrofuro[2,3-b]quinolin-4-yl)-2-(2-oxopyrrolidin-1-yl)acetamide.

Molecular Formula:

The molecular formula of Coluracetam is C19H23N3O3.

Formula Weight:

The formula weight of Coluracetam is 341.41 g/mol.


The CAS number of Coluracetam is 135463-81-9.

Top Ten Keywords from Google and Synonyms:

  1. Nootropic Supplement
  2. Cognitive Enhancer
  3. Memory Booster
  4. Neuroprotective Agent
  5. Brain Health Supplement
  6. Smart Drug
  7. Focus Improver
  8. Learning Aid
  9. Choline Uptake Enhancer
  10. Racetam Compound

Health Benefits of Coluracetam:

Coluracetam is believed to provide various health benefits due to its potential cognitive-enhancing effects. Some of the potential benefits of Coluracetam include:

  1. Improved Memory: Coluracetam may improve memory and learning ability by enhancing choline uptake in the brain.

  2. Increased Focus: Coluracetam may increase focus and attention by modulating acetylcholine levels in the brain.

  3. Neuroprotection: Coluracetam may have neuroprotective effects by increasing NGF (nerve growth factor) production in the brain.

Potential Effects:

Coluracetam can produce a range of effects depending on the dosage and individual response. Some of the potential effects of Coluracetam include:

  1. Improved Memory: Coluracetam may improve memory and learning ability by enhancing choline uptake in the brain.

  2. Increased Focus: Coluracetam may increase focus and attention by modulating acetylcholine levels in the brain.

  3. Mood Enhancement: Coluracetam may enhance mood and reduce anxiety by modulating glutamate receptors in the brain.

Product Mechanism:

Coluracetam works by enhancing the activity of choline uptake in the brain, which leads to increased levels of acetylcholine. Acetylcholine is an important neurotransmitter involved in memory and learning processes. By increasing NGF production, Coluracetam also provides neuroprotective effects.


Coluracetam can be safe when used appropriately and under medical supervision. However, it can cause adverse effects if misused or abused. Some of the potential side effects of Coluracetam include:

  1. Headaches: Coluracetam may cause headaches in some individuals.

  2. Insomnia: Coluracetam may cause insomnia in some individuals.

Dosing Information:

The appropriate dose of Coluracetam depends on several factors such as age, weight, and health status. It is essential to follow dosing instructions carefully and not exceed the recommended dose.


Coluracetam is a nootropic compound that is believed to enhance cognitive function and improve memory. While Coluracetam may provide some health benefits, it should only be used under medical supervision and with caution due to its potential side effects. Additionally, more research is needed to fully understand its safety and efficacy in humans

Health Benefits: Coluracetam is a nootropic compound that is suggested to provide several potential health benefits, including improvements in memory, focus, and attention. It may be useful for individuals seeking to improve their cognitive performance for academic, work and other pursuits. Coluracetam has also shown potential therapeutic uses against various neurological disorders such as Alzheimer's and dementia.

Potential Effects: The potential effects of Coluracetam can include improved memory, enhanced focus and attention, increased sensory perception, and mood improvement. Coluracetam may also increase the ability to retain verbal information, improve memory retention for numbers, or improve decision-making speed.

Mechanisms: It is thought that Coluracetam works primarily by increasing the expression of high-affinity choline uptake (HACU), which leads to more acetylcholine being made available to neurons within the brain. Acetylcholine is a key neurotransmitter that helps to communicate signals between neurons that are responsible for memory and attention, and so increasing its availability may result in improved cognitive functioning. Coluracetam has also been suggested to partly work by modulation of glutamate receptors which are associated with neuroplasticity and cognitive enhancement.

Safety and Side-Effects: Largely speaking, Coluracetam appears to be well-tolerated and safe when used appropriately. Side effects may occur, but are generally mild and infrequent, and may include headaches, gastrointestinal distress, and dizziness. Some anecdotal evidence suggests that higher dosages in the range of several hundred milligrams per day may lead to restlessness, irritability and anxiety. It is recommended that Coluracetam should not be used in people with a history of mental health problems and should be used in moderation. It is best to consult with your healthcare professional before considering using Coluracetam.

Dosage Information: There is no universally accepted optimal dosage of Coluracetam. Recommended dosages usually range between 10-40 mg per day, but some may choose to take higher doses with some success. It is best to start with a lower dosage and gradually work up to a suitable dosage for individual preferences and tolerances. It is essential to ensure that dosages stay within safe limits, and any adverse reactions should always be reported to a healthcare provider immediately. Coluracetam has a short half life, so it may be safer to split the dosage into several smaller does throughout the day.


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