Fasudil hydrochloride Hcl is a small molecule inhibitor produced by Asahi Kasei Pharma. It has been shown to have therapeutic potential in various diseases, including stroke, pulmonary hypertension, and Alzheimer's disease. The chemical name of Fasudil hydrochloride Hcl is 5-(1,4-Diazepane-1-sulfonyl)isoquinoline hydrochloride. Its molecular formula is C14H17N3O2S•HCl, its formula weight is 327.83g/mol, and its CAS number is 105628-07-7.
Top Ten Keywords and Synonyms
According to a Google search for Fasudil hydrochloride Hcl, these are the top ten keywords related to it: "stroke", "pulmonary hypertension", "Alzheimer's disease", "cerebral vasospasm", "central nervous system disorders", "clinical trial", "neuroprotection", "ischemia-reperfusion injury", "vascular smooth muscle cells", and "protein kinase inhibitor".
Some of the Synonyms for Fasudil hydrochloride Hcl include HA1077, AT877, MEK-IN-1, HA 1077 hydrochloride, and (5-Isoquinolinesulfonyl)-1,4-diazepane hydrochloride.
Health Benefits of Fasudil Hydrochloride Hcl
Fasudil hydrochloride Hcl has been shown to have beneficial effects in the treatment of various diseases such as stroke, pulmonary hypertension, and Alzheimer's disease. It can improve blood flow, reduce inflammation, and protect brain cells from damage. Fasudil hydrochloride Hcl has also been found to have anti-proliferative effects on cancer cells and may have a potential role in cancer treatment.
Potential Effects
Fasudil hydrochloride Hcl is a potent inhibitor of Rho-associated protein kinases (ROCKs), which are involved in the regulation of cellular processes such as smooth muscle contraction, cell adhesion, and cell proliferation. By inhibiting ROCKs, Fasudil hydrochloride Hcl can improve blood flow, reduce inflammation, and protect cells from damage in various diseases. Fasudil hydrochloride Hcl may also act as a neuroprotective agent by inhibiting the formation of toxic protein aggregates in the brain.
Product Mechanism
The molecular mechanism of Fasudil hydrochloride Hcl involves the inhibition of ROCKs, which are a family of serine/threonine kinases that play a critical role in cellular processes such as cytoskeleton remodeling, cell motility, and cell proliferation. By inhibiting ROCK activity, Fasudil hydrochloride Hcl can relax vascular smooth muscle cells, improve blood flow, reduce inflammation, and protect cells from injury in various disease conditions.
Safety of Fasudil Hydrochloride Hcl
Studies of Fasudil hydrochloride Hcl have shown that it can be administered safely to humans at doses that induce therapeutic effects. Fasudil hydrochloride Hcl has been given safely to patients in clinical trials of stroke, pulmonary hypertension, and Alzheimer's disease. In general, it is well tolerated, and most adverse events are mild and transient.
Side Effects
The side effects of Fasudil hydrochloride Hcl are generally mild, with the most common side effects being headache, dizziness, and nausea. Rarely, Fasudil hydrochloride Hcl can cause hypotension and bradycardia, and caution should be exercised when administering Fasudil hydrochloride Hcl to patients with cardiovascular disease.
Dosing Information
The dosage of Fasudil hydrochloride Hcl varies depending on the disease being treated and the patient's condition. In clinical trials, doses ranging from 15 mg/d to 60 mg/d have been used, and the duration of treatment varies depending on the disease being treated.
Conclusion
Fasudil hydrochloride Hcl is a promising therapeutic agent with a broad range of clinical applications. As a ROCK inhibitor, it has been shown to have potential benefits in the treatment of various diseases such as stroke, pulmonary hypertension, and Alzheimer's disease. Fasudil hydrochloride Hcl has also been found to have anti-proliferative effects on cancer cells and may have a potential role in cancer treatment. Ongoing research continues to provide more insights into its efficacy and safety profile. With further clinical trials, Fasudil hydrochloride Hcl may develop into a significant drug for treating a variety of diseases.
