Fisetin, also known by its chemical name 3,3',4',7-tetrahydroxyflavone, is a naturally occurring flavonoid found in various fruits and vegetables. Fisetin has gained significant attention in recent years due to its potential health benefits and possible therapeutic effects.
Chemical Properties The molecular formula of fisetin is C15H10O6 and its formula weight is 286.24 g/mol. The CAS number for fisetin is 528-48-3.
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Other synonyms for fisetin include 2-(3,4-dihydroxyphenyl)-3,7-dihydroxychromen-4-one, 3,7,3',4'-tetrahydroxyflavone, and 7,3',4'-flavonetriol.
Health Benefits Fisetin has been shown to have a variety of potential health benefits. One of the most well-known benefits of fisetin is its antioxidant properties. As an antioxidant, fisetin helps to protect cells from oxidative stress caused by free radicals, which can lead to cellular damage and even cell death. Fisetin has also been shown to have anti-inflammatory properties, which may help to reduce inflammation throughout the body.
In addition to its antioxidant and anti-inflammatory properties, fisetin has also been shown to have neuroprotective effects. Studies have shown that fisetin may help to protect neurons in the brain from damage, potentially reducing the risk of neurological disorders such as Alzheimer's disease and Parkinson's disease.
Another potential benefit of fisetin is its senolytic properties. Senolytics are compounds that selectively target and eliminate senescent cells, which are cells that have stopped dividing and started producing harmful inflammatory molecules. By eliminating these cells, fisetin may help to delay the aging process and reduce the risk of age-related diseases.
Potential Effects In addition to its health benefits, fisetin may have other potential effects. Studies have suggested that fisetin may have anti-cancer properties, particularly in regard to breast and prostate cancer. Fisetin has also been shown to improve insulin sensitivity, which could be beneficial in the treatment and prevention of type 2 diabetes.
Product Mechanism The mechanism of action of fisetin is not completely understood, but it has been shown to modulate several signaling pathways involved in inflammation, oxidative stress, and cellular senescence. Fisetin has been shown to activate the Nrf2 pathway, a signaling pathway involved in the regulation of antioxidant and detoxification enzymes. Additionally, fisetin has been shown to activate SIRT1, a protein involved in the regulation of cellular metabolism and aging.
Safety and Side Effects Fisetin appears to be generally safe for consumption, with no serious adverse effects reported in human studies. However, high doses of fisetin may cause gastrointestinal upset, including nausea and diarrhea. Individuals taking blood thinners should exercise caution when taking fisetin since it may have anticoagulant properties.
Dosing Information There is currently no established dose of fisetin for humans. However, fisetin supplements typically contain doses ranging from 100 mg to 500 mg per day. It is always recommended to consult with a healthcare professional before starting any new supplement regimen.
Conclusion Fisetin is a naturally occurring flavonoid with potential health benefits and therapeutic effects. Its antioxidant, anti-inflammatory, neuroprotective and senolytic properties make it a promising compound for the treatment and prevention of a variety of diseases. While more research is needed to fully understand the mechanisms of action of fisetin, it appears to be generally safe for consumption at recommended doses.