Ingenol-3-angelate is a natural compound derived from the sap of the Euphorbia peplus plant. It has gained significant attention in recent years due to its potential therapeutic effects on different cancers, including skin cancer. Ingenol-3-angelate is also known as PEP005 and is currently being studied in clinical trials for its anti-cancer properties.
The chemical name for Ingenol-3-angelate is (1aR,1bS,4aS,7aR,7bS,8R,9R,9aS)-1b-acetoxy-9-hydroxy-9a-methyl-7-(1-oxobutyl)-octahydro-1a,5,8-trimethylspiro(naphthalene-2,4'-piperidine)-4,7-dione.
The molecular formula for Ingenol-3-angelate is C25H34O6.
The formula weight for Ingenol-3-angelate is 430.53 g/mol.
The CAS number for Ingenol-3-angelate is 75567-37-2.
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Health Benefits of this Product:
Ingenol-3-angelate has shown promising health benefits in various preclinical and clinical studies. Some of the potential health benefits are discussed below.
Anti-Cancer Effects: Ingenol-3-angelate has potent anti-cancer effects that have been demonstrated in various types of cancers, including basal cell carcinoma, squamous cell carcinoma, melanoma, and leukemia. It induces tumor cell death by activating protein kinase C (PKC), which leads to the production of reactive oxygen species, activation of caspases, and inhibition of pro-survival signaling pathways. It also stimulates the immune system by promoting the release of pro-inflammatory cytokines like tumor necrosis factor-alpha (TNF-α).
Wound Healing: Ingenol-3-angelate has been shown to promote wound healing by stimulating the proliferation and migration of keratinocytes, fibroblasts, and endothelial cells. It also enhances angiogenesis by increasing the expression of vascular endothelial growth factor (VEGF).
Anti-Inflammatory Effects: Ingenol-3-angelate has anti-inflammatory effects that can reduce inflammation in various inflammatory diseases like psoriasis and ulcerative colitis. It inhibits the production of pro-inflammatory cytokines like interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α).
Apart from the above-discussed health benefits, Ingenol-3-angelate has several other potential effects that are being studied.
Antiviral Effects: Ingenol-3-angelate may have antiviral effects against human immunodeficiency virus (HIV), herpes simplex virus (HSV), and influenza virus. It inhibits viral replication by blocking the transcription and translation of viral genes.
Analgesic Effects: Ingenol-3-angelate may have analgesic effects by reducing pain sensation through the modulation of ion channels and neurotransmitters.
Ingenol-3-angelate exerts its biological effects by binding to and activating PKC, which is a key enzyme involved in cell signaling and regulation. The activation of PKC leads to the phosphorylation of downstream signaling molecules, which regulate various cellular processes, including cell growth, differentiation, and apoptosis. Ingenol-3-angelate activates two isoforms of PKC, PKCα, and PKCδ, which play a crucial role in its anti-cancer and anti-inflammatory effects.
Ingenol-3-angelate is generally safe to use when applied topically to the skin under medical supervision. However, it may cause local skin reactions like erythema, edema, and blistering at the site of application. It should not be applied to open wounds or mucous membranes.