Isoliquiritigenin is a natural flavonoid derived from licorice root. It has gained attention for its potential health benefits and therapeutic properties in various diseases. Isoliquiritigenin targets several signaling pathways involved in inflammation, oxidative stress, and cancer cell proliferation, making it a promising candidate for the development of novel therapeutics.
Chemical name:
2',4',4-Trihydroxychalcone
Molecular formula:
C15H12O4
Formula weight:
256.25 g/mol
CAS No:
961-29-5
Top ten keywords from Google and Synonyms:
Health benefits of this product:
Isoliquiritigenin has shown potential health benefits in the treatment of various diseases, including inflammation, oxidative stress, and cancer. Studies have shown that isoliquiritigenin can inhibit the production of pro-inflammatory cytokines and chemokines, reduce oxidative stress, and induce apoptosis in cancer cells. Additionally, isoliquiritigenin has been found to have anti-metastatic effects, inhibiting the migration and invasion of cancer cells.
Potential effects:
Isoliquiritigenin has several potential effects on the body. One of the primary mechanisms is through the inhibition of several signaling pathways involved in inflammation and oxidative stress, including NF-κB and Nrf2. Isoliquiritigenin has also been found to induce apoptosis in cancer cells, as well as inhibit angiogenesis and metastasis. Additionally, isoliquiritigenin has been found to have neuroprotective effects, improving cognitive function and reducing neuronal damage.
Product mechanism:
Isoliquiritigenin works by targeting several signaling pathways involved in inflammation, oxidative stress, and cancer cell proliferation. One of the primary mechanisms is through the inhibition of NF-κB and Nrf2 signaling pathways, which play key roles in cellular responses to stress and inflammation. By inhibiting these pathways, isoliquiritigenin can reduce oxidative stress and inflammation. Additionally, isoliquiritigenin has been found to induce apoptotic cell death in cancer cells, inhibit angiogenesis and metastasis, and have neuroprotective effects.
Safety:
Isoliquiritigenin has been found to be generally safe in preclinical studies. However, further research is needed to determine the safety and efficacy of isoliquiritigenin in humans.
Side effects:
Currently, there is limited information available regarding the potential side effects of isoliquiritigenin. Some studies have reported mild adverse events such as nausea and gastrointestinal disturbances. Further research is needed to determine the full extent of the drug's side effects.
Dosing information:
There are currently no established guidelines for the dosing of isoliquiritigenin in humans. Doses used in preclinical studies have ranged from 2.5 to 200 mg/kg. Further research is needed to determine the optimal dosing regimen for isoliquiritigenin in humans.
Conclusion:
Isoliquiritigenin is a versatile natural product with potential health benefits in the treatment of various diseases, including inflammation, oxidative stress, and cancer. The drug has been shown to target several signaling pathways involved in these diseases, making it a promising candidate for the development of novel therapeutics. However, its safety and efficacy in humans need to be further studied. Overall, isoliquiritigenin shows great promise as a targeted therapy for various diseases, and may provide valuable insights into the development of future treatments for inflammatory and neoplastic disorders
