Jervine is a toxic steroidal alkaloid obtained from plants belonging to the Veratrum genus. This compound has been historically used as a medicinal agent for its ability to stimulate labor and induce vomiting. However, jervine has also been associated with severe toxicity and adverse effects, limiting its therapeutic potential.
Chemical name: Veratramine Molecular formula: C27H39NO2 Formula weight: 417.61 g/mol CAS No: 469-59-0
Top ten keywords from Google:
- Jervine synthesis
- Veratramine biosynthesis
- Jervine structure
- Veratrum alkaloids
- Toxicity of jervine
- Jervine poisoning
- Jervine mechanism of action
- Jervine pharmacology
- Medicinal uses of jervine
- Side effects of jervine
Synonyms: (-)-veratramine; (3β,5α,12β)-3,23-dihydroxy-14-veratroyloxy-5β-cardenolide; veratramine; 3β-hydroxy-12β-(3,4,5-trimethoxybenzoyloxy)-5α-spirostan-14β-lactone
Health benefits of this product: Jervine has been traditionally used in Chinese medicine to treat various ailments, including headaches, coughs, and pain related to arthritis. It has also been used as an emetic to induce vomiting and in obstetrics to promote labor. However, due to its toxicity, the use of jervine as a therapeutic agent is limited.
Potential effects: Jervine can have both acute and chronic effects on the human body. Acute exposure to jervine can cause symptoms such as nausea, vomiting, abdominal pain, headache, dizziness, and even death in severe cases. Chronic exposure to jervine can lead to liver and kidney damage, neurological disorders, and even cancer.
Product mechanism: Jervine acts by inhibiting the activity of the Na+/K+ ATPase pump, leading to an accumulation of potassium ions in the extracellular space and sodium ions inside the cell. This causes depolarization of the cell membrane and subsequent activation of voltage-gated calcium channels. The influx of calcium ions triggers the release of neurotransmitters, resulting in a variety of physiological effects.
Safety: Jervine is highly toxic and should be handled with extreme caution. It is not recommended for use in humans due to its potential for severe adverse effects. Exposure to jervine can occur through ingestion, inhalation, or skin contact. If exposed to jervine, seek medical attention immediately.
Side effects: The side effects of jervine are numerous and can be severe. Acute exposure can result in gastrointestinal symptoms such as nausea, vomiting, and abdominal pain. Neurological symptoms such as tremors, convulsions, and coma can also occur. Chronic exposure can lead to liver and kidney damage, neurological disorders, and even cancer.
Dosing information: Due to its toxicity, jervine is not recommended for use in humans. There is no established safe dose of jervine, and even small amounts can be lethal.
In conclusion, jervine is a toxic steroidal alkaloid that has been historically used for its medicinal properties. However, due to its potential for severe adverse effects, the use of jervine as a therapeutic agent is limited. Exposure to jervine can occur through ingestion, inhalation, or skin contact, and even small amounts can be lethal. Therefore, it is essential to handle jervine with extreme caution and seek medical attention immediately if exposed