LY-310762 hydrochloride is a potent and selective inhibitor of phosphodiesterase 4D (PDE4D), an enzyme that plays a critical role in the regulation of inflammatory responses in the body. In this article, we will delve into the chemical properties of LY-310762 hydrochloride, its health benefits, potential effects, mechanism of action, possible side effects, and dosing information.
Chemical Properties
The chemical name of LY-310762 hydrochloride is 3-(1-methyl-5-(pyridin-4-yl)-1H-1,2,3-triazol-4-yl)-1-(4-pyridin-4-ylbutoxy)-8-(trifluoromethyl)quinoline hydrochloride. Its molecular formula is C30H25F3N6O.HCl and formula weight is 599.02 g/mol. The CAS number of LY-310762 hydrochloride is 192927-92-7.
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Health Benefits
LY-310762 hydrochloride has shown potential benefits in treating chronic obstructive pulmonary disease (COPD) and asthma by reducing inflammation in the lungs. It may also have applications in other immune-mediated diseases such as neurodegenerative disorders.
Potential Effects
LY-310762 hydrochloride primarily acts as an inhibitor of PDE4D, an enzyme that plays a critical role in regulating the levels of cyclic adenosine monophosphate (cAMP) in the body. By inhibiting PDE4D, LY-310762 hydrochloride can increase cAMP levels, which ultimately reduces inflammation and improves immune function. This may contribute to the treatment of various inflammatory diseases such as COPD, asthma, and neurodegenerative disorders.
Product Mechanism
PDE4D is an enzyme that breaks down cAMP, a molecule that plays a critical role in regulating immune function and inflammation. LY-310762 hydrochloride selectively inhibits PDE4D, thereby increasing cAMP levels and reducing inflammation in the body.
Safety
LY-310762 hydrochloride has demonstrated a good safety profile in preclinical studies. However, there is limited information on its safety in humans, and further research is needed to determine its long-term safety and potential toxicities.
Side Effects
There is limited information on the side effects of LY-310762 hydrochloride in humans. In animal studies, it has been shown to cause mild gastrointestinal disturbances and changes in heart rate and blood pressure, but these effects are generally reversible and do not affect overall health or wellbeing.
Dosing Information
LY-310762 hydrochloride has been administered orally in preclinical studies at doses ranging from 0.01 to 10 mg/kg. The optimal dose and duration of treatment for various inflammatory diseases are unknown, and further research is needed to establish safe and effective dosing regimens.
Conclusion
LY-310762 hydrochloride is a promising PDE4D inhibitor with potential therapeutic applications in reducing inflammation and improving immune function in various inflammatory diseases such as COPD, asthma, and neurodegenerative disorders. Its mechanism of action involves increasing cAMP levels and reducing inflammation by selectively inhibiting PDE4D. While it has demonstrated a good safety profile in preclinical studies, more research is needed to determine its long-term safety and potential side effects in humans. Nonetheless, LY-310762 hydrochloride has great potential as a novel therapeutic agent in the treatment of various inflammatory diseases.
