Madecassoside CAS: 34540-22-2

CAS NO: 34540-22-2
CBNumber: CB6210654
Chemical Name: Madecassoside
Molecular Formula: C48H78O20
Formula Weight: 975.12
CAS No.: 34540-22-2
Description Review

Madecassoside is an active compound extracted from Centella asiatica, a popular medicinal plant commonly found in Asia, Africa, and South America. It is a triterpenoid saponin and belongs to the group of pentacyclic triterpenoids. Madecassoside was first isolated in 1968 by Japanese scientists, and since then, its therapeutic potential has been extensively studied. The chemical formula for Madecassoside is C48H78O20, and its CAS number is 34540-22-2.

Chemical Name and Formula

The chemical name of Madecassoside is (2α,3β,4α)-2,3,23-trihydroxyurs-12-en-28-oic acid 28-O-β-D-glucopyranosyl ester. The molecular formula for Madecassoside is C48H78O20, and the structure is shown below.

Formula Weight

Madecassoside has a molecular weight of 975.15 g/mol.


Madecassoside has a CAS number of 34540-22-2.

Top Searched Keywords on Google and Synonyms on Google

Some of the top searched keywords for Madecassoside on Google include Madecassoside cream, Madecassoside serum, Madecassoside skin benefits, and Madecassoside anti-aging. Some of the synonyms for Madecassoside include Asiaticoside B, Madecassic acid glycoside, and Centella asiatica extract.

Health Benefits

Madecassoside has numerous potential health benefits, which have been widely studied. Some of these benefits include:

  1. Anti-inflammatory properties: Madecassoside has been found to have potent anti-inflammatory properties. Studies have shown that it can reduce inflammation by inhibiting the production of cytokines and chemokines.

  2. Wound healing: Madecassoside has been shown to have significant wound healing properties. It can stimulate collagen synthesis, increase angiogenesis, and enhance the migration of fibroblasts.

  3. Anti-aging: Madecassoside has been found to have anti-aging properties. It can promote the production of elastin and collagen, which can help reduce wrinkles and other signs of aging.

  4. Skin hydration: Madecassoside has been shown to improve skin hydration by increasing the production of hyaluronic acid.

  5. Anti-microbial activity: Madecassoside has been found to have anti-microbial activity against a range of gram-positive and gram-negative bacteria. This makes it useful in the treatment of infections.

Potential Effects

Madecassoside has several potential effects that may be beneficial for health. Some of these effects include:

  1. Reduces inflammation: Madecassoside has been found to reduce inflammation and may be useful in the treatment of inflammatory conditions such as arthritis and Crohn's disease.

  2. Stimulates collagen synthesis: Madecassoside can stimulate collagen synthesis, which can help improve skin elasticity and reduce the appearance of wrinkles.

  3. Increases angiogenesis: Madecassoside can increase angiogenesis, which is the formation of new blood vessels. This can be beneficial for wound healing and the treatment of conditions such as diabetic foot ulcers.

  4. Improves skin hydration: Madecassoside can improve skin hydration by increasing the production of hyaluronic acid.


Madecassoside exerts its therapeutic effects through several mechanisms. Some of these mechanisms include:

  1. Inhibition of cytokine and chemokine production: Madecassoside can inhibit the production of cytokines and chemokines, which are pro-inflammatory molecules.

  2. Stimulation of collagen synthesis: Madecassoside can stimulate the synthesis of collagen, which is the main structural protein in the skin.

  3. Promotion of angiogenesis: Madecassoside can promote angiogenesis, which can improve blood flow and promote wound healing.

  4. Increase in hyaluronic acid production: Madecassoside can increase the production of hyaluronic acid, which is a natural moisturizer in the skin.


Madecassoside is generally considered to be safe when used as directed. However, some people may experience side effects such as skin irritation or allergic reactions. It is recommended to conduct a patch test before using any product containing Madecassoside, especially if you have sensitive skin. If you experience any adverse effects, discontinue use and seek medical attention.


Madecassoside may cause some side effects, especially if used in high concentrations or for extended periods. Some of the potential side effects include:

  1. Skin irritation: Madecassoside may cause skin irritation in some people. This can manifest as redness, itching, or burning.

  2. Allergic reactions: Some people may develop an allergic reaction to Madecassoside. This can cause symptoms such as swelling, hives, or difficulty breathing.

Dosage Information

The recommended dosage for Madecassoside varies depending on the product and its intended use. For skin care products, the recommended concentration of Madecassoside is up to 0.1%. It is important to follow the instructions on the product label and avoid using excessive amounts of Madecassoside.


Madecassoside is a triterpenoid saponin found in Centella asiatica that has numerous potential health benefits. Its anti-inflammatory and wound healing properties make it useful for the treatment of a range of conditions. Madecassoside is generally considered safe when used as directed, although some people may experience side effects such as skin irritation or allergic reactions. Before using any product containing Madecassoside, it is recommended to conduct a patch test and follow the instructions on the label.


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