PHA-767491 Dihydrochloride Salt is a chemical compound that is commonly used in cancer research. The chemical name for PHA-767491 Dihydrochloride Salt is 1-(6-(3-methoxyphenyl)-4-oxo-2-thioxo-3,4-dihydropyrimidin-1(2H)-yl)-3-(trifluoromethyl)urea dihydrochloride salt. The molecular formula of this compound is C16H14F3N4O3S and its formula weight is 434.37 g/mol. The CAS No for PHA-767491 Dihydrochloride Salt is 845714-00-3. This article will provide information on various aspects of PHA-767491 Dihydrochloride Salt, including its health benefits, potential side effects, dosing information, mechanisms of action, and safety information.
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Health Benefits: PHA-767491 Dihydrochloride Salt has been found to have several health benefits, including its effectiveness in treating various forms of cancer. The product has been shown to inhibit checkpoint kinase 1 (Chk1), which is involved in the DNA damage response pathway. Therefore, PHA-767491 Dihydrochloride Salt can effectively sensitize cancer cells to chemotherapy and radiation therapy by inhibiting the cell cycle and inducing apoptosis. The compound can also influence the cell cycle by inducing cell cycle arrest in cancer cells.
Potential Effects: PHA-767491 Dihydrochloride Salt has been shown to have various potential effects, including sensitizing cancer cells to chemotherapy and radiation therapy. The product can enhance the effectiveness of DNA-damaging agents by inhibiting the repair of cancer cells' DNA, thereby leading to their death. The Chk1 inhibitor can also influence the cell cycle by inducing cell cycle arrest and apoptosis in cancer cells. Studies have shown that the product is effective in treating various types of tumors, including lung, colon, and breast cancers.
Product Mechanisms: PHA-767491 Dihydrochloride Salt works by inhibiting Chk1, which is a key protein in the DNA damage response pathway. The Chk1 inhibitor can enhance the effectiveness of DNA-damaging agents by inhibiting the repair of cancer cells' DNA, leading to their death. Additionally, PHA-767491 Dihydrochloride Salt can influence the cell cycle by inducing cell cycle arrest and apoptosis in cancer cells.
Safety: Studies have shown that PHA-767491 Dihydrochloride Salt is generally safe to use, but like any medication, it can have side effects. The product has been shown to cause hematological toxicities, such as anemia, thrombocytopenia, and neutropenia, which can lead to an increased risk of infection or bleeding. It can also cause gastrointestinal toxicities, such as nausea, vomiting, diarrhea, and abdominal pain. Cardiovascular toxicities, including QTc prolongation and arrhythmias, have also been observed as side effects of PHA-767491 Dihydrochloride Salt.
Side Effects: The most common side effects of PHA-767491 Dihydrochloride Salt include hematological toxicities, such as anemia, thrombocytopenia, and neutropenia, which can lead to an increased risk of infection or bleeding. It can also cause gastrointestinal toxicities, such as nausea, vomiting, diarrhea, and abdominal pain. Cardiovascular toxicities, including QTc prolongation and arrhythmias, have also been observed as side effects of PHA-767491 Dihydrochloride Salt.
Dosing Information: The dosing information for PHA-767491 Dihydrochloride Salt varies depending on the indication and the stage of cancer. In clinical studies, the product has been administered at doses ranging from 0.1 mg/kg to 20 mg/kg. The dosing regimen may also vary depending on the route of administration, as PHA-767491 Dihydrochloride Salt can be administered orally or intravenously. Patients should always follow their healthcare provider's dosing instructions.
Conclusion: PHA-767491 Dihydrochloride Salt is a potent anticancer agent that is effective in treating various forms of cancer. The product works by inhibiting checkpoint kinase 1 (Chk1), which is involved in the DNA damage response pathway. Therefore, PHA-767491 Dihydrochloride Salt can effectively sensitize cancer cells to chemotherapy and radiation therapy by inhibiting the cell cycle and inducing apoptosis. While the product is generally safe to use, it can have potentially severe side effects, including hematological toxicities, gastrointestinal toxicities, and cardiovascular toxicities. It is essential to carefully monitor patients receiving PHA-767491 Dihydrochloride Salt for any potential adverse effects
