Roscovitine is a small molecule inhibitor of cyclin-dependent kinases (CDKs) that is commonly used in cancer research. It is also known as Seliciclib and CYC202. Roscovitine is a white, crystalline powder that is soluble in DMSO and water.
Chemical Name:
Roscovitine's chemical name is N6-(2-hydroxyethyl)-9-isopropyl-7-methyl-2-(5-oxa-4,6-diazacycloheptan-4-ylamino) pyrido[2,3-d]pyrimidin-4(3H)-one.
Molecular formula:
The molecular formula of Roscovitine is C19H26N6O2.
Formula Weight:
The formula weight of Roscovitine is 362.45 g/mol.
CAS No:
The CAS number of Roscovitine is 186692-46-6.
Top Ten Keywords from Google and Synonyms:
Synonyms:
Synonyms of Roscovitine include:
• Seliciclib • CYC202 • R-roscovitine • (R)-Roscovitine • S-roscovitine • (S)-Roscovitine
Health benefits of this product:
Roscovitine has several potential health benefits, including the suppression of tumor growth in cancer cells. Roscovitine's mechanism of action induces apoptosis in cancer cells and causes cell cycle arrest, effectively preventing the proliferation of cancer cells. This drug also shows promising results in the treatment of leukemia, where it can effectively reduce leukemia cell proliferation and induce apoptosis.
Potential effects:
Roscovitine is a CDK inhibitor that can prevent the proliferation of cancer cells by inducing cell cycle arrest and apoptosis. It has also been shown to reduce inflammation and neurodegeneration. The compound can also help regulate insulin secretion.
Product mechanism:
Roscovitine works by inhibiting the function of cyclin-dependent kinases (CDKs), which are enzymes that regulate the cell cycle. By inhibiting CDKs, Roscovitine can induce cell cycle arrest effectively, leading to decreased proliferation of cancer cells. Roscovitine also enhances the Bax/Bcl-2 ratio, which is associated with the activation of apoptosis. Additionally, Roscovitine inhibits the activation of cyclin E by CDK2, which leads to the suppression of tumor proliferation.
Safety:
Roscovitine is a safe drug, but its use should be monitored by a medical professional. It is not recommended for pregnant women and breastfeeding mothers. Patients with liver or kidney disease should consult a doctor before using Roscovitine.
Side effects:
The side effects of Roscovitine can include:
Dosing information:
The dosing information for Roscovitine should be determined by a healthcare professional. Roscovitine is usually administered as a tablet, and it is given three times per week.
Conclusion:
Roscovitine is a small molecule inhibitor of cyclin-dependent kinases that is commonly used in cancer research. It can induce cell cycle arrest and apoptosis in cancer cells effectively, leading to the suppression of tumor growth. Roscovitine shows promising results in the treatment of leukemia, and it can also help regulate insulin secretion. While it is a safe drug, it should be monitored by a medical professional. The dosing of Roscovitine should only be determined by a healthcare professional.
