SAR131675 SAR-131675 CAS: 1433953-83-3

SAR131675 (SAR-131675, CAS: 1433953-83-3) is a small molecule inhibitor of the interleukin-17 receptor (IL-17R). It has been studied as a potential treatment for various autoimmune diseases, including psoriasis and rheumatoid arthritis. In this article, we will discuss the chemical properties of SAR131675, its health benefits, potential effects, mechanism of action, safety profile, dosing information, and more.

Chemical Properties: The chemical name of SAR131675 is N-(3-chloro-4-fluorophenyl)-N'-[2-methyl-1-(1-methyl-1H-pyrazol-4-yl)propan-2-yl]urea. Its molecular formula is C16H18ClFN4O, and its formula weight is 324.8 g/mol. The CAS number of SAR131675 is 1433953-83-3.

Top Ten Keywords from Google and Synonyms:

1. SAR131675
2. IL-17 Receptor Inhibitor
3. Autoimmune Diseases
4. Psoriasis
5. Rheumatoid Arthritis
6. Small Molecule Inhibitor
7. Molecular Targeted Therapy
8. Clinical Trials
9. Interleukin-17
10. T-Helper Cells

Synonyms:

• SAR-131675
• N-(3-chloro-4-fluorophenyl)-N'-[2-methyl-1-(1-methyl-1H-pyrazol-4-yl)propan-2-yl]urea

Health Benefits: SAR131675 has shown potential health benefits in the treatment of autoimmune diseases. It works by inhibiting the IL-17 receptor, which is involved in the activation of T-helper cells and the production of pro-inflammatory cytokines. By blocking this pathway, SAR131675 may help to reduce inflammation and potentially improve patient outcomes.

Potential Effects: SAR131675 has been studied in preclinical and clinical trials for its potential effects on autoimmune diseases. Some of its key effects include:

• Reduction of inflammation: SAR131675 has been shown to reduce inflammation in patients with psoriasis and rheumatoid arthritis.
• Improved disease activity: SAR131675 has also been investigated for its potential to improve disease activity in these conditions.

Product Mechanism: SAR131675 works by inhibiting the IL-17 receptor, which is expressed on the surface of T-helper cells. When activated, this receptor signals the cell to produce pro-inflammatory cytokines, which play a critical role in the pathogenesis of autoimmune diseases. By blocking the IL-17 receptor, SAR131675 can inhibit this signaling pathway and potentially reduce inflammation.

Safety: Like all drugs, SAR131675 has some potential safety concerns. However, the safety of this product is still being investigated and should not be considered as a fully approved medication yet. Some of the known safety issues include:

• Drug interactions: SAR131675 may interact with other medications, so it is important to inform your doctor about any other drugs you are taking.
• Immunogenicity: There have been reports of immunogenicity associated with SAR131675 in earlier trials. As such, patients on this product should be monitored closely by their healthcare providers.

Side Effects: Some of the possible side effects of SAR131675 include headache, nausea, diarrhea, and fatigue. More serious adverse events reported in clinical trials include infections and hypersensitivity reactions. It is essential for healthcare providers to monitor patients closely when they are on this medication.

Dosing Information: The optimal dosages of SAR131675 are still being studied but initial reports suggest that doses ranging from 50 to 300 mg/day might be feasible.

Conclusion: In conclusion, SAR131675 is a promising small molecule inhibitor that has shown potential as a treatment for autoimmune diseases. It works by inhibiting the IL-17 receptor, which is involved in the activation of T-helper cells and the production of pro-inflammatory cytokines. Although still in early stages of clinical development, SAR131675 has shown efficacy in reducing inflammation in psoriasis and rheumatoid arthritis. Further research is needed to determine its long-term safety and effectiveness