SNS 314 mesylate is a small molecule inhibitor of Aurora kinase A and B, which are enzymes involved in the regulation of cell division. Aurora kinases play an important role in the progression of cancer by promoting tumor growth and metastasis. SNS 314 mesylate inhibits Aurora kinase activity, potentially slowing or stopping the proliferation of cancer cells. The chemical name of SNS 314 mesylate is (R)-N-(4-(2-((3-chloro-2-(pyridin-2-yl)phenyl)amino)-5-methylpyrimidin-4-yl)piperazin-1-yl)propionamide methanesulfonate, and its molecular formula is C25H28ClN7O3S.CH4O3S. Its formula weight is 645.18 g/mol, and its CAS number is 1146618-41-8.
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Synonyms for SNS 314 mesylate include N-[4-[2-[3-chloro-2-(pyridin-2-yl)phenyl]amino]-5-methylpyrimidin-4-yl]piperazin-1-yl]propanamide methanesulfonate, SNS-314, and SNS314.
Health benefits of SNS 314 mesylate:
SNS 314 mesylate's potential health benefits lie in its ability to inhibit Aurora kinases A and B, both of which play a role in cancer growth and metastasis. SNS 314 mesylate has shown promise in preclinical studies as a potential treatment for various types of cancer, including glioblastoma and non-Hodgkin lymphoma.
Potential effects:
Preclinical studies have demonstrated that SNS 314 mesylate can induce cell cycle arrest and apoptosis in cancer cells. Additionally, it has been suggested that inhibition of Aurora kinases may sensitize cancer cells to chemotherapy, making them more susceptible to traditional cancer treatments.
Product mechanism:
SNS 314 mesylate inhibits Aurora kinases A and B, leading to the disruption of proper cell division and potentially inducing apoptosis in cancer cells. In addition, inhibition of Aurora kinases may also affect cellular signaling pathways involved in cell survival and proliferation.
Safety:
While SNS 314 mesylate has shown promise in preclinical studies, there is still much research to be done before it can be considered safe for human use. Some studies have noted potential toxicity to normal cells, and more research is needed to determine the safety profile of this compound.
Side effects:
As with any medication or potential treatment, there is always the possibility of side effects. Preclinical studies of SNS 314 mesylate have noted potential gastrointestinal disturbances, such as nausea, vomiting, and diarrhea. Additional side effects may include fatigue, headache, and respiratory infections.
Dosing information:
Currently, there is no established dosing information for SNS 314 mesylate in humans, as it is still in the early stages of development. However, preclinical studies have provided some insight into the optimal dosing regimen for use in animal models, which may guide future clinical trials.
Conclusion:
SNS 314 mesylate has shown promise as a potential treatment for various types of cancer due to its ability to inhibit Aurora kinases A and B. While much more research is needed before it can be considered safe for human use, preclinical studies have provided valuable insight into the potential therapeutic applications of this compound. Further research will be necessary to establish its safety profile, determine appropriate dosing regimens, and assess its potential for use in various cancer types
