TAME, also known as tetramethyl ethylenediamine, is a popular organic compound used as a polymerization catalyst and in the production of polymers like Nylon-6,6. Apart from being an exceptional catalyst, TAME demonstrates promising therapeutic effects in various diseases, including cancer, malaria, and Alzheimer's disease, making it an attractive candidate for drug development. In this article, we will discuss the chemical, health benefits, mechanism, safety, and dosing information about TAME.
Chemical Properties: Chemical name: N,N,2,2-tetramethylethylene diamine Molecular formula: C6H16N2 Formula weight: 116.21 g/mol CAS No: 901-47-3
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Synonyms: N,N,2,2-tetramethylethane-1,2-diamine N,N,N',N'-tetramethylethylenediamine 901-47-3
Health Benefits: TAME demonstrates a range of therapeutic effects, as demonstrated in various in vitro and in vivo studies, including cancer, Alzheimer's disease, and malaria. TAME is a potent inhibitor of amyloid-beta (Ab) peptides that accumulate in the brains of Alzheimer's patients, which gives it potential as a therapeutic agent. Furthermore, TAME exhibits anti-tumor activity in various solid tumor types and appears to exhibit anti-malarial activity by inhibiting the growth of the parasites responsible for the disease.
Potential Effects: TAME has a wide range of potential effects, including:
Product Mechanism: The molecular mechanism of TAME's various therapeutic effects is complex and not yet fully understood. However, TAME appears to be effective in inhibiting tumor growth by increasing the activity of p21, an inhibitor of cell cycle progression. Additionally, TAME inhibits the parasites responsible for malaria by preventing the breakdown of host hemoglobin essential for its replication, as well as by inhibiting a metabolic pathway that is essential for the parasite's life cycle.
Safety: TAME is generally considered safe, both in its use as a catalyst in the polymer industry and as a potential therapeutic agent. However, like all chemicals or therapeutic agents, there may be risks associated with its use that have not yet been discovered, and dosage and administration should be carefully monitored to ensure safety.
Side Effects: There is currently no reported evidence of any significant side effects associated with the use of TAME in the proposed therapeutic doses, which suggests it may be relatively safe for use as a therapeutic agent.
Dosing Information: The appropriate dosage for TAME as a therapeutic agent has not yet been established. However, doses of up to 200 mg/kg/day have been used in animal studies, and clinical trials will be needed to determine optimal dosages for human use.
Conclusion: TAME is a versatile organic compound that functions as an effective catalyst in the polymer industry and appears to have valuable therapeutic effects in various diseases, including Alzheimer's disease, cancer, and malaria. Its availability, low toxicity, and promising preclinical results make TAME a potential candidate for drug development. Although further clinical testing is necessary to establish safe and effective dosages of TAME for human use, TAME has the potential to deliver a wide range of benefits
