Tanshinone II A is a natural compound found in the roots of Salvia miltiorrhiza, also known as Danshen. Its chemical name is 1,6,6-trimethyl-7-oxabicyclo [2.2.1] heptan-2-one and its molecular formula is C19H18O3, with a molecular weight of 294.35 g/mol. The CAS number for tanshinone II A is 568-72-9.
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Health Benefits of Tanshinone II A: Tanshinone II A has been used in traditional Chinese medicine for its various health benefits. Recent studies have shown that it possesses antioxidant, anti-inflammatory, cardiovascular, neuroprotective and anticancer properties.
Antioxidant Properties: Tanshinone II A has potent antioxidant properties which help to scavenge free radicals and reduce oxidative stress in cells. These properties make it a potential therapeutic agent for various chronic diseases such as cancer, neurodegenerative disorders, and cardiovascular diseases.
Anti-inflammatory Effects: Tanshinone II A exerts an anti-inflammatory effect by inhibiting the expression of pro-inflammatory cytokines and enzymes such as interleukin-1 beta (IL-1β), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α) and cyclooxygenase-2 (COX-2). This makes it a potential treatment for inflammatory diseases such as rheumatoid arthritis and asthma.
Cardiovascular Benefits: Tanshinone II A has beneficial effects on the cardiovascular system by reducing blood pressure, improving endothelial function and preventing platelet aggregation. These properties make it a potential treatment for hypertension, atherosclerosis, and other cardiovascular diseases.
Neuroprotective Effects: Tanshinone II A has neuroprotective effects by inhibiting oxidative stress, reducing inflammation and reducing neuronal apoptosis. These properties make it a potential therapy for neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease.
Anticancer Activity: Tanshinone II A has been found to possess anticancer activity by inhibiting cell proliferation, inducing cell cycle arrest and promoting apoptosis in various cancer cells. It has been studied for its potential use in treating cancers of the breast, lung, colon and liver.
Product Mechanism: The therapeutic effects of Tanshinone II A are thought to be mediated through several mechanisms. It activates the Nrf2 pathway which regulates antioxidant and cytoprotective gene expression. It also modulates various signaling pathways involved in inflammation, oxidative stress, and apoptosis. Tanshinone II A inhibits the activation of NF-κB, a transcription factor that plays a key role in regulating the expression of genes involved in inflammation and immune responses.
Safety and Side Effects: Tanshinone II A is generally considered safe when used as directed. However, high doses or prolonged use may cause gastrointestinal upset, headache and dizziness. It is also known to interact with certain medications such as anticoagulants, antiplatelets, and chemotherapy agents.
Dosing Information: There is no standard dosing for tanshinone II A because it depends on the condition being treated. However, typical doses range from 50 to 200 mg per day, taken orally.
In Conclusion: Tanshinone II A is a natural compound with promising therapeutic potential. Its antioxidant, anti-inflammatory, cardiovascular, neuroprotective and anticancer properties make it a valuable candidate for the development of new drugs. However, more research is needed to determine its efficacy, safety, and optimal dosing in humans. As with any dietary supplement, it is important to consult a healthcare professional before taking tanshinone II A
