Thiazovivin is a synthetic small molecule that is used as a selective inhibitor of the Rho-associated protein kinase (ROCK) signaling pathway. ROCK signaling plays a crucial role in cell survival, differentiation, proliferation, and cell shape. Thiazovivin acts as an inhibitor of ROCK signaling, leading to a change in cellular behavior, including stem cell differentiation and maintenance. Thiazovivin has been found to exert beneficial effects in the treatment of a range of diseases including heart disease, cancer, and neurological conditions.
Chemical name: 2-(3-Morpholinyl)-6-(1-thioxo-1,2,6-thiadiazinan-4-yl)pyrimidin-4(3H)-one Molecular formula: C12H15N5O2S2 Formula weight: 317.42 g/mol CAS No: 1226056-71-8
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Synonyms: N-(6-(1-thioxo-1,2,6-thiadiazinan-4-yl)-2-(morpholino)pyrimidin-4-yl)acetamide
Health Benefits of Thiazovivin: Thiazovivin has been shown to have a range of useful health benefits. It has been studied for its potential use in treating heart disease, cancer, and neurological conditions. For example, thiazovivin has been shown to be effective in promoting the differentiation of stem cells, which could be useful in the treatment of neurological conditions such as Parkinson's disease. Additionally, thiazovivin has demonstrated anti-tumor properties and has been shown to be effective in reducing the size of tumors in mice models.
Potential Effects: The effects of thiazovivin are primarily achieved through its inhibition of the Rho-associated protein kinase (ROCK) signaling pathway. By inhibiting this pathway, thiazovivin can modulate cell behavior and differentiation. Thiazovivin has been found to be effective in promoting the differentiation of stem cells, which offers a range of potential therapeutic applications. Thiazovivin has also demonstrated anti-tumor properties, which may make it an effective treatment for cancer.
Product Mechanism: Thiazovivin inhibits the activity of Rho-associated protein kinase (ROCK) signaling by selectively targeting ROCK1 and ROCK2. This leads to reduced cell contractility, decreased migration of cells, and modulated cell growth and differentiation. Through this mechanism, thiazovivin impacts stem cell differentiation, tumor cell migration, and various other cellular functions.
Safety: Thiazovivin has demonstrated relatively low toxicity in various studies. However, as with all medications, it is important to consult with a healthcare provider prior to taking thiazovivin, particularly if you have any pre-existing medical conditions that may be impacted by its use.
Side Effects: Thiazovivin has been found to be relatively safe, but there may still be some side effects associated with its usage. For example, some animal studies have suggested that thiazovivin may cause embryo toxicity, which could limit its use in pregnant women. Additionally, thiazovivin may cause reduced platelet aggregation and bleeding, so individuals who have a bleeding disorder should exercise caution when considering taking thiazovivin.
Dosing Information: The dosing of thiazovivin varies greatly depending on the specific condition being treated and the individual patient. As with all medications, it is important to follow dosing instructions closely and to be aware of any potential side effects.
Conclusion: Thiazovivin is a synthetic small molecule that acts as a selective inhibitor of the Rho-associated protein kinase (ROCK) signaling pathway. Its effects are primarily achieved through the inhibition of ROCK1 and ROCK2, leading to benefits such as enhanced stem cell differentiation and anti-tumor properties. While thiazovivin has demonstrated relatively low toxicity, it is important to consult with a healthcare provider prior to taking thiazovivin to ensure that it is a safe and appropriate treatment for your specific condition.
