Tyrphostin AG490 (also known as AG-490) is a chemical compound that is used in scientific research as a JAK-2 specific inhibitor. This inhibition has potential applications in treating certain medical conditions related to abnormal cell growth and inflammation.
Chemical name: The chemical name of Tyrphostin AG490 is 2-(2'-chloro-4'-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide.
Molecular formula: The molecular formula of Tyrphostin AG490 is C17H14ClF2IN2O2.
Formula weight: The molecular weight of Tyrphostin AG490 is 463.66 g/mol.
CAS No: The CAS number of Tyrphostin AG490 is 133550-30-8.
Top ten keywords from Google and synonyms:
Synonyms: • AG-490 • NSC 36524 • 2-(2'-Chloro-4'-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide • Tyrosine kinase inhibitor AG490
Health benefits of this product: Tyrphostin AG490 inhibits the activity of the enzyme JAK-2, which plays a role in various cellular processes like signal transduction, cell proliferation, and differentiation. By inhibiting JAK-2, Tyrphostin AG490 can potentially affect these processes, leading to changes in cell behavior, including cell cycle arrest or apoptosis. This inhibition has potential applications in treating certain medical conditions related to abnormal cell growth and inflammation, such as cancer and autoimmune diseases.
Potential effects: Tyrphostin AG490 inhibits the activity of the enzyme JAK-2, which plays a role in various cellular processes like signal transduction, cell proliferation, and differentiation. By inhibiting JAK-2, Tyrphostin AG490 can potentially affect these processes, leading to changes in cell behavior, including cell cycle arrest or apoptosis. This inhibition has potential applications in treating certain medical conditions related to abnormal cell growth and inflammation, such as cancer and autoimmune diseases.
Product mechanism: Tyrphostin AG490 inhibits the activity of the enzyme JAK-2 by binding to the ATP-binding site of the enzyme. JAK-2 is involved in various cellular processes, including signal transduction, cell proliferation, and differentiation. By inhibiting JAK-2, Tyrphostin AG490 can block these processes and potentially reduce abnormal cell growth and inflammation.
Safety: Tyrphostin AG490 is mainly used in scientific research and has not been approved for human use. Its safety in humans is not well established, and there may be potential side effects associated with its use. Individuals should seek advice from a healthcare professional before using Tyrphostin AG490.
Side effects: The potential side effects of Tyrphostin AG490 are not well-established as it is primarily used in scientific research. However, there may be potential risks associated with its use, including toxicity and effects on normal cell growth.
Dosing information: Tyrphostin AG490 is mainly used in scientific research and dosing information is determined based on the specific experiment being performed. Individuals should consult with a qualified scientist or healthcare professional for guidance on appropriate dosing.
Conclusion: Tyrphostin AG490 is a chemical compound that is commonly used in scientific research as a JAK-2 specific inhibitor. The inhibition of JAK-2 has potential applications in treating certain medical conditions related to abnormal cell growth and inflammation, such as cancer and autoimmune diseases. Although mainly used in scientific research, potential side effects and safety concerns should be taken into consideration if considering its use. Further studies are needed to determine the safety and efficacy of Tyrphostin AG490 for human use
