Vinflunine is a medication used for the treatment of advanced or metastatic transitional cell carcinoma of the urothelial tract. It is a semi-synthetic vinca alkaloid that acts as a microtubule inhibitor, preventing cell division and growth. Vinflunine is administered intravenously, and it has been found to have potential health benefits in treating cancer.
Chemical name:
The chemical name of vinflunine is 5',12'-dihydroxy-3'-methoxy-6'-[7-(3-methylbut-2-enyl)indolizino[8,7-b]indole]-5,17-(2H,14H)-dione.
Molecular formula:
The molecular formula of vinflunine is C45H54N4O8.
Formula weight:
The formula weight of vinflunine is 778.94 g/mol.
CAS No:
The CAS number of vinflunine is 162652-95-1.
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Synonyms:
Vinflunine is also known as Javlor, 20'-norvincaleukoblastine, and 5,17-Anhydro-5'-(aminocarbonyl)-20'-deoxy-20'-norvincaleukoblastine.
Health Benefits of Vinflunine:
Vinflunine is primarily used for the treatment of advanced or metastatic transitional cell carcinoma of the urothelial tract. It has been found to have a significant impact on patient outcomes, including improved progression-free survival and overall survival rates. In addition to its use in cancer treatment, vinflunine may have potential health benefits due to its ability to inhibit cell division and growth.
Potential Effects of Vinflunine:
Vinflunine has several potential effects due to its ability to inhibit cell division and growth. These include:
Anti-cancer effects: Vinflunine has been found to be effective in the treatment of advanced or metastatic transitional cell carcinoma of the urothelial tract.
Anti-proliferative effects: Vinflunine can inhibit cell proliferation by preventing cell division and growth.
Anti-angiogenic effects: Vinflunine can inhibit the formation of new blood vessels, which is critical for tumor growth and survival.
Product Mechanism:
Vinflunine works by inhibiting microtubule dynamics, which are essential for cell division and growth. By inhibiting microtubule dynamics, vinflunine prevents the formation of mitotic spindles, which are necessary for cell division. Vinflunine also disrupts the formation of new blood vessels, which is critical for tumor growth and survival.
Safety:
Vinflunine is generally safe when used in recommended amounts. However, it can cause mild to moderate side effects such as fatigue, nausea, vomiting, constipation, and peripheral neuropathy.
Side Effects:
Some individuals may experience more severe side effects, such as neutropenia, anemia, and thrombocytopenia. Vinflunine can also cause hypersensitivity reactions, which can be life-threatening in some cases.
Dosing Information:
The recommended dose of vinflunine is 320 mg/m2 every three weeks. The dosage may be adjusted based on individual patient factors, such as age, body weight, and renal function.
Conclusion:
Vinflunine is a medication used for the treatment of advanced or metastatic transitional cell carcinoma of the urothelial tract. It is a microtubule inhibitor that prevents cell division and growth. Vinflunine has been found to have significant health benefits in treating cancer and improving patient outcomes. Vinflunine works by inhibiting microtubule dynamics and disrupting the formation of new blood vessels. Vinflunine is generally safe when used in recommended amounts, although it can cause side effects such as fatigue, nausea, vomiting, and peripheral neuropathy. Further research is needed to determine the optimal dosages and potential side effects of vinflunine in treating different types of cancer
