Withaferin A is a bioactive compound found in the root of the Withania somnifera plant, also known as ashwagandha. Withaferin A has been traditionally used in Ayurvedic medicine for its anti-inflammatory, anti-tumor, and anti-stress properties. It is being studied extensively for its potential health benefits in several areas of medicine.
The chemical name of withaferin A is 4-(methoxycarbonyl)-2-[(3S,5S,6R,8S,9S,10S,13S,14S,17S)-3,6,10,13,17-pentahydroxy-1,7,9-trimethyl-16-oxo-2,3,4,5,6,7,8,11,12,14,15,16-dodecahydro-1H-cyclopenta[a]phenanthren-11-ylidene]butyl ester.
The molecular formula of withaferin A is C28H38O6.
The formula weight of withaferin A is 470.59 g/mol.
The CAS number of withaferin A is 5119-48-2.
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Withaferin A is also known as 4-beta-hydroxywithanolide E, NSC-101088, and 20,22-Dihydroxy-6beta-(3'-methyl-2'-butenyl)-5beta,24beta-ergostadienolide.
Health Benefits of Withaferin A:
Withaferin A has many potential health benefits due to its anti-inflammatory, anti-tumor, anti-stress, and antioxidant properties. Some of these benefits include:
Anti-cancer effects: Withaferin A has been found to have potent anti-cancer effects and may help prevent the growth and spread of cancer cells.
Anti-inflammatory effects: Withaferin A has been shown to have anti-inflammatory effects, which can help reduce inflammation throughout the body.
Neuroprotective effects: Withaferin A has been found to have neuroprotective effects and may help protect against neurological disorders.
Anti-stress effects: Withaferin A has been found to help reduce stress and anxiety levels.
Antioxidant effects: Withaferin A has been found to have potent antioxidant effects, which can help protect the body against oxidative stress and free radical damage.
Potential Effects of Withaferin A:
Withaferin A has several potential effects due to its anti-inflammatory, anti-tumor, anti-stress, and antioxidant properties. These include:
Improved cognitive function: Withaferin A has been found to improve cognitive function and memory.
Cardiovascular health: Withaferin A may help improve cardiovascular health by reducing inflammation and preventing the buildup of plaque in the arteries.
Pain relief: Withaferin A has been used in traditional medicine to relieve pain and reduce inflammation.
Withaferin A works by inhibiting various key cellular pathways that drive tumor proliferation and survival. It also exerts its anti-inflammatory and antioxidant effects through the modulation of various signaling pathways. Additionally, withaferin A has been shown to promote apoptosis, a process in which damaged or abnormal cells are eliminated.
Withaferin A is generally considered safe when used in recommended amounts. However, some individuals may be allergic to withaferin A, and it can cause gastrointestinal upset in sensitive individuals.
Withaferin A can cause gastrointestinal upset, including nausea, vomiting, and diarrhea, in some individuals. It may also cause headaches and dizziness in some people.
There is no established dosage for withaferin A supplements. However, most supplements contain 5-25 mg of withaferin A per capsule. It is recommended to start with a low dose and gradually increase the dose if needed.
Withaferin A is a bioactive compound found in the root of the Withania somnifera plant, also known as ashwagandha. Withaferin A has been traditionally used in Ayurvedic medicine for its