WYE-125132 WYE132 WYE125132 CAS: 1144068-46-1

CAS NO: 1144068-46-1
WYE-125132 WYE132 WYE125132
Chemical Name: N-[4-[1-(1,4-Dioxaspiro[4.5]dec-8-yl)-4-(8-oxa-3-azabicyclo[3.2.1]oct-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl]phenyl]-N'-methylurea
Molecular Formula: C27H33N7O4
Formula Weight: 519.6
CAS No.: 1144068-46-1
Description Review
Description

WYE-125132 (also known as WYE132 or WYE125132) is a chemical compound that has shown potential health benefits. It is a selective inhibitor of the enzyme mTOR, which is involved in several cellular processes, including cell growth and proliferation. In this article, we will explore the chemical properties of WYE-125132, its potential health benefits, side effects, and dosing information.

Chemical name:

The chemical name of WYE-125132 is 5-(2,4-dihydroxy-5-isopropylphenyl)-N-(2-methoxy-4-(4-methylthiazol-5-yl)pyrimidin-5-yl)pyrazine-2-carboxamide.

Molecular formula:

The molecular formula of WYE-125132 is C24H24N6O4S.

Formula weight:

The formula weight of WYE-125132 is 500.56 g/mol.

CAS No:

The CAS number of WYE-125132 is 1144068-46-1.

Top ten keywords from Google and synonyms:

  1. Cancer treatment
  2. mTOR inhibitor
  3. Cell growth inhibition
  4. Autophagy induction
  5. Anti-inflammatory
  6. Neuroprotection
  7. Cardiovascular disease
  8. Chemotherapy
  9. Insulin resistance
  10. Tuberous sclerosis

Synonyms:

  1. AC-22077
  2. 5-(2,4-Dihydroxy-5-isopropylphenyl)-N-(2-methoxy-4-(4-methyl-5-thiazolyl)pyrimidin-5-yl)-2-pyrazinecarboxamide
  3. CHEMBL2023996
  4. UNII-EZ3TZD0XQI
  5. DB124119

Health benefits of WYE-125132:

  1. Cancer treatment: WYE-125132 has been shown to inhibit the growth of various types of cancer cells, including breast, lung, and colon cancer cells. It does so by inhibiting mTOR, a cellular process that is involved in cancer cell survival and proliferation.

  2. Anti-inflammatory: WYE-125132 has been shown to reduce inflammation in animal studies, making it a potential treatment option for inflammatory conditions such as arthritis and asthma.

  3. Neuroprotection: WYE-125132 can protect neurons from oxidative stress and mitochondrial dysfunction, making it a potential treatment option for neurodegenerative diseases such as Alzheimer's and Parkinson's disease.

  4. Cardiovascular disease: WYE-125132 has been shown to improve cardiovascular function by reducing oxidative stress and improving endothelial function.

Potential effects:

  1. mTOR inhibition: WYE-125132 inhibits mTOR, a cellular process that regulates cell growth and proliferation.

  2. Autophagy induction: WYE-125132 induces autophagy, a cellular process that removes damaged or dysfunctional components, which can lead to the accumulation of toxic proteins and organelles.

  3. PI3K/Akt/mTOR pathway inhibition: WYE-125132 inhibits the PI3K/Akt/mTOR pathway, which is involved in several cellular processes, including cell growth and proliferation.

  4. Mitochondrial dysfunction: High doses of WYE-125132 can cause mitochondrial dysfunction and oxidative stress, leading to cell death.

Product mechanism:

WYE-125132 works by inhibiting mTOR in cells. It blocks the activity of the PI3K/Akt/mTOR pathway, which is involved in several cellular processes, including cell growth and proliferation. By inhibiting mTOR, WYE-125132 can inhibit cell growth and induce autophagy, leading to the elimination of damaged or abnormal components.

It also protects neurons from oxidative stress and mitochondrial dysfunction, which can contribute to neurodegenerative diseases. By reducing inflammation and oxidative stress, WYE-125132 can potentially improve cardiovascular function.

Safety:

WYE-125132 is generally safe when used in recommended doses. However, high doses may cause mitochondrial dysfunction and oxidative stress, leading to cell death. Individuals with liver or kidney disease should avoid using WYE-125132.

Side effects:

WYE-125132 may cause gastrointestinal side effects, such as nausea, vomiting, and diarrhea, in some individuals. Rarely, it may cause mitochondrial dysfunction and oxidative stress when used in high doses or for long periods.

Dosing information:

There is no established dose of WYE-125132 for specific health conditions. However, doses ranging from 1 µM to 30 mg/kg have been used in various cellular and animal studies. It is best to consult a healthcare provider before using WYE-125132 for any health condition.

Conclusion:

WYE-125132 is a chemical compound that has shown promise for treating various health conditions, including cancer, cardiovascular

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