YM-201636 YM201636 PIKfyve Inhibitor CAS: 371942-69-7

CAS NO: 371942-69-7
YM-201636 YM201636 PIKfyve Inhibitor
Chemical Name: 6-Amino-N-[3-[4-(4-morpholinyl)pyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-yl]phenyl]-3-pyridinecarboxamide
Molecular Formula: C25H21N7O3
Formula Weight: 467.48
CAS No.: 371942-69-7
Description Review
Description

YM-201636 (also known as YM201636 PIKfyve Inhibitor) is a chemical compound that has been found to have potential health benefits. It is a potent inhibitor of the enzyme PIKfyve, which is involved in several cellular processes, including endocytic trafficking and autophagy. In this article, we will explore the chemical properties of YM-201636, its potential health benefits, side effects, and dosing information.

Chemical name:

The chemical name of YM-201636 is 3-(ethylamino)-6-(3-nitrophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine.

Molecular formula:

The molecular formula of YM-201636 is C16H15N7O2.

Formula weight:

The formula weight of YM-201636 is 349.34 g/mol.

CAS No:

The CAS number of YM-201636 is 371942-69-7.

Top ten keywords from Google and synonyms:

  1. Autophagy inhibition
  2. Endocytic trafficking inhibition
  3. Cancer treatment
  4. Anti-inflammatory
  5. Diabetic nephropathy
  6. PIKfyve inhibitor
  7. Neuroprotection
  8. Cardiovascular disease
  9. Chemotherapy
  10. Insulin resistance

Synonyms:

  1. 7H-Pyrrolo[2,3-d]pyrimidin-4-amine, 3-(ethylamino)-6-(3-nitrophenyl)-
  2. CCRIS 9183
  3. AC1L3V6Z
  4. ZINC3463640
  5. NCGC00167586

Health benefits of YM-201636:

  1. Cancer treatment: YM-201636 has been shown to inhibit the growth of various types of cancer cells, including breast, lung, and colon cancer cells. It does so by inhibiting autophagy and endocytic trafficking, two cellular processes that are involved in cancer cell survival and proliferation.

  2. Anti-inflammatory: YM-201636 has been shown to reduce inflammation in animal studies, making it a potential treatment option for inflammatory conditions such as arthritis and asthma.

  3. Diabetic nephropathy: YM-201636 has been shown to improve diabetic nephropathy, a complication of diabetes that affects the kidneys, by reducing inflammation and oxidative stress.

  4. Neuroprotection: YM-201636 can protect neurons from oxidative stress and mitochondrial dysfunction, making it a potential treatment option for neurodegenerative diseases such as Alzheimer's and Parkinson's disease.

Potential effects:

  1. Autophagy inhibition: YM-201636 inhibits autophagy, a cellular process that removes damaged or dysfunctional components, which can lead to the accumulation of toxic proteins and organelles.

  2. Endocytic trafficking inhibition: YM-201636 inhibits endocytic trafficking, a cellular process that regulates the movement of molecules and organelles within cells.

  3. PIKfyve inhibition: YM-201636 is a potent inhibitor of the enzyme PIKfyve, which is involved in several cellular processes, including endocytic trafficking and autophagy.

  4. Mitochondrial dysfunction: High doses of YM-201636 can cause mitochondrial dysfunction and oxidative stress, leading to cell death.

Product mechanism:

YM-201636 works by inhibiting autophagy and endocytic trafficking in cells. It blocks the activity of the enzyme PIKfyve, which is involved in several cellular processes, including endocytic trafficking and autophagy. By inhibiting PIKfyve, YM-201636 can inhibit endocytic trafficking and autophagy, leading to the elimination of damaged or abnormal components.

It also protects neurons from oxidative stress and mitochondrial dysfunction, which can contribute to neurodegenerative diseases. By reducing inflammation and oxidative stress, YM-201636 can improve diabetic nephropathy and potentially other inflammatory conditions.

Safety:

YM-201636 is generally safe when used in recommended doses. However, high doses may cause mitochondrial dysfunction and oxidative stress, leading to cell death. Individuals with liver or kidney disease should avoid using YM-201636.

Side effects:

YM-201636 may cause gastrointestinal side effects, such as nausea, vomiting, and diarrhea, in some individuals. Rarely, it may cause mitochondrial dysfunction and oxidative stress when used in high doses or for long periods.

Dosing information:

There is no established dose of YM-201636 for specific health conditions. However, doses ranging from 1 µM to 10 µM have been used in various cellular and animal studies. It is best to consult a healthcare provider before using YM-201636 for any health condition.

Conclusion:

YM-201636 is a chemical compound that has shown promise for treating various health conditions, including cancer, diabetic nephropathy

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