Chemical Name: JNJ-42847922
Molecular Formula: C21H22FN7O
Formula Weight: 407.44
CAS No.: 1293281-49-8
Seltorexant, also known as JNJ-42847922, is a selective and potent antagonist of the orexin-2 receptor (OX2R). Orexins, also known as hypocretins, are neuropeptides produced in the hypothalamus that play a key role in regulating the sleep-wake cycle, arousal, and appetite. By selectively blocking OX2R, Seltorexant reduces wakefulness and promotes sleep, showing significant promise as a treatment for insomnia and depression associated with sleep disturbances.
Mechanism of Action
Seltorexant’s mechanism revolves around antagonizing the OX2R in the central nervous system. Orexin-A and orexin-B, the two endogenous ligands for OX1R and OX2R, modulate the sleep-wake cycle. The OX2R, primarily found in brain regions that control arousal and vigilance, is more heavily involved in maintaining wakefulness. By blocking OX2R, Seltorexant dampens the orexin signaling pathway, leading to a reduction in arousal and promotion of sleep. This targeted action allows Seltorexant to produce sedative effects without significantly affecting cognitive function or producing next-day residual effects often associated with other sleep aids.
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