5,7-Dimethoxyflavone is a flavone compound found in a variety of plants including Tilia spp. (lime blossoms) and Passiflora spp. (passionflowers). It has been studied for its potential health benefits and a number of studies suggest that it may have neuroprotective, anxiolytic, and anti-inflammatory effects. In this article, we will explore the various aspects of 5,7-Dimethoxyflavone.
Chemical Properties: 5,7-Dimethoxyflavone is a yellow crystalline substance that is soluble in organic solvents such as ethanol and DMSO. It has a melting point of 236-238 °C and a boiling point of 433.7 °C at 760 mmHg.
Top Searched Keywords on Google and Synonyms on Google: Some of the top searched keywords and synonyms for 5,7-Dimethoxyflavone are:
Keywords: 5,7-Dimethoxyflavone, Tilia spp., Passiflora spp., neuroprotection, anxiolytic, anti-inflammatory, apoptosis, antioxidant, anti-cancer. Synonyms: 5,7-Dimethoxy-2-phenylchromen-4-one; 5,7-Dimethoxyflavone; 4H-1-Benzopyran-4-one, 5,7-dimethoxy-2-phenyl-; 4H-1-Benzopyran-4-one, 5,7-dimethoxy-2-phenyl-; 5,7-Dimethoxyflavone; 5,7-Dimethoxy-2-phenyl-4H-chromen-4-one
Health Benefits: 5,7-Dimethoxyflavone has been studied for its potential health benefits. Some of these benefits are discussed below:
Neuroprotection: A number of studies have suggested that 5,7-Dimethoxyflavone may have neuroprotective effects. In one study, it was found to decrease the level of free radicals and inhibit apoptosis in a model of Parkinson's disease. It also reduced inflammation and oxidative stress in the brain.
Anxiety: Another study assessed the anxiolytic effects of 5,7-Dimethoxyflavone. It was shown to reduce anxiety-like behavior in mice and improve their performance in a maze test.
Anti-inflammatory: 5,7-Dimethoxyflavone has been shown to have anti-inflammatory effects. It was found to suppress the production of inflammatory cytokines and reduce inflammation in a model of rheumatoid arthritis.
Antioxidant: Studies have also suggested that 5,7-Dimethoxyflavone has antioxidant properties. It was found to scavenge free radicals and reduce oxidative stress in cells.
Anti-cancer: Preliminary studies have suggested that 5,7-Dimethoxyflavone may have anti-cancer properties. It was found to inhibit the growth of cancer cells in vitro and in vivo.
Mechanisms: The potential mechanisms of action of 5,7-Dimethoxyflavone are not fully understood. However, it is believed to exert its effects through a number of mechanisms including antioxidant, anti-inflammatory, and anti-apoptotic actions. It has also been suggested that it may modulate the activity of various signaling pathways, such as the PI3K/Akt pathway and the NF-κB pathway.
Safety: There is limited information available on the safety of 5,7-Dimethoxyflavone. However, it has been reported to have low toxicity in animal studies. It may also interact with certain medications, so it is important to consult with a healthcare professional before taking any supplements containing this compound.
Side-Effects: There have been no reported side effects of 5,7-Dimethoxyflavone in human clinical trials. However, some animal studies have noted that it may cause mild gastrointestinal side effects.
Dosage Information: There is currently no established dosage for 5,7-Dimethoxyflavone. However, some supplements contain doses ranging from 20-200 mg per serving.
Conclusion: 5,7-Dimethoxyflavone is a flavone compound found in various plants that has been studied for its potential health benefits, including neuroprotection, anxiolytic, anti-inflammatory, antioxidant, and anti-cancer effects. It appears to exert these effects through different mechanisms of action, such as antioxidant and anti-inflammatory actions. There is limited information on the safety and dosage of 5,7-Dimethoxyflavone, and it is important to consult with a healthcare professional before taking any supplements containing this compound.