Introduction In the realm of dermatological treatments, the advent of AN2728 Crisaborole, a nonsteroidal anti-inflammatory drug, has marked a significant milestone. This topical agent, known for its brand name Eucrisa, has emerged as a beacon of hope for patients suffering from mild to moderate atopic dermatitis, commonly referred to as eczema.
Chemical Name and Identity Crisaborole, chemically known as 4-(benzoxazol-2-yl)-1,2-dihydrophthalazin-1-one, is a small molecule with a unique structure that distinguishes it from other treatments.
Molecular Formula and Weight The molecular formula of Crisaborole is C14H10N2O2, and it has a formula weight of 251.24 g/mol, which contributes to its pharmacokinetic properties.
CAS Number The compound is registered under the CAS number 906673-24-3, ensuring its distinct identity in the chemical databases.
Keywords and Synonyms In the digital age, visibility on search engines is crucial. Top ten keywords associated with Crisaborole might include 'atopic dermatitis treatment', 'nonsteroidal eczema ointment', 'PDE4 inhibitor', 'Eucrisa', 'topical skin inflammation treatment', 'steroid-free eczema therapy', 'Crisaborole mechanism of action', 'eczema side effects management', 'Crisaborole safety profile', and 'AN2728 efficacy'. Synonyms for Crisaborole include AN2728, Eucrisa, and PDE4 inhibitor ointment.
Competitive Products Crisaborole faces competition from several other eczema treatments, including topical corticosteroids like hydrocortisone, calcineurin inhibitors such as tacrolimus (Protopic) and pimecrolimus (Elidel), and the newer biologic dupilumab (Dupixent).
Health Benefits Crisaborole offers significant health benefits by alleviating the symptoms of atopic dermatitis, such as itching, redness, and inflammation, without the common side effects associated with steroids.
Potential Effects The potential effects of Crisaborole extend beyond symptom relief, potentially improving the quality of life for eczema sufferers by reducing the frequency and severity of flare-ups.
Product Mechanism Crisaborole functions by selectively inhibiting phosphodiesterase 4 (PDE4), an enzyme implicated in the inflammatory processes of atopic dermatitis. This inhibition reduces the production of pro-inflammatory cytokines.
Safety and Side Effects The safety profile of Crisaborole is favorable, with the most common side effects being site application pain and irritation. Its nonsteroidal nature makes it a suitable option for long-term management of eczema.
Dosing Information Crisaborole is typically prescribed as a 2% ointment, applied twice daily to the affected areas. It is crucial to follow healthcare provider instructions for optimal outcomes.
Contraindications Crisaborole is contraindicated in patients with known hypersensitivity to Crisaborole or any of its components. Caution is advised when considering use in patients with a history of severe allergic reactions.
Conclusion Crisaborole stands out as a revolutionary treatment in the management of atopic dermatitis. Its unique mechanism of action and favorable safety profile make it an attractive option for patients, especially those who are either intolerant or unresponsive to traditional steroid treatments. As research continues, Crisaborole may pave the way for more innovative treatments in dermatology, improving the lives of those with chronic skin conditions.
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