Bendamustine hydrochloride (HCl) is a chemotherapy drug that is used for the treatment of certain types of cancer, including chronic lymphocytic leukemia (CLL) and non-Hodgkin's lymphoma. This article provides an overview of bendamustine hydrochloride, including its chemical formula, health benefits, potential effects, product mechanism, safety, side effects, and dosing information.
Chemical name, Molecular formula, Formula weight, and CAS No:
The chemical name of Bendamustine hydrochloride is 4-{5-[bis(2-chloroethyl)amino]-1-methylbenzimidazol-2-yl}butyric acid hydrochloride. Its molecular formula is C16H21Cl2N3O2.HCl, and its formula weight is 394.23 g/mol. The CAS number for Bendamustine HCl is 3543-75-7.
Top ten keywords from Google and Synonyms Synonym:
Synonyms for Bendamustine hydrochloride include Bendamustine HCl, Bendamustin, Ribomustin, and SDX-105.
Health benefits of bendamustine hydrochloride:
Bendamustine hydrochloride is an alkylating agent that is used for the treatment of chronic lymphocytic leukemia (CLL) and non-Hodgkin's lymphoma. It works by damaging the DNA of cancer cells, causing them to die. Bendamustine hydrochloride has been shown to improve overall survival and progression-free survival in patients with CLL and non-Hodgkin's lymphoma.
Potential effects of bendamustine hydrochloride:
In addition to its antitumor activity, bendamustine hydrochloride has been shown to have immunomodulatory effects, meaning it can help to modulate the immune system's response to cancer. Bendamustine hydrochloride has also been shown to have antiviral and anti-inflammatory properties.
Product mechanism:
Bendamustine hydrochloride is an alkylating agent that works by damaging the DNA of cancer cells. This causes the cancer cells to die or become unable to divide and grow. Bendamustine hydrochloride works by interfering with several stages of cell division, including DNA replication and repair.
Safety:
Bendamustine hydrochloride is generally well-tolerated, but it can cause some side effects. The most common side effects of Bendamustine hydrochloride include nausea, fatigue, fever, and chills. Other side effects can include low blood cell counts, allergic reactions, and secondary cancer. Bendamustine hydrochloride should not be used by patients who have a history of allergic reactions to the drug or its components.
Side effects:
Bendamustine hydrochloride can cause a range of side effects, including nausea, fatigue, fever, and chills. It can also cause low blood cell counts, which can increase the risk of infection, bleeding, and anemia. Allergic reactions to Bendamustine hydrochloride can include rash, itching, and difficulty breathing. Bendamustine hydrochloride can also increase the risk of secondary cancer, including leukemia. Patients who experience any side effects from Bendamustine hydrochloride should contact their healthcare provider immediately.
Dosing information:
Bendamustine hydrochloride is administered via intravenous infusion over a period of 30-60 minutes. The recommended dose of Bendamustine hydrochloride for CLL is 100 mg/m2 on days 1 and 2 of a 28-day cycle. The recommended dose of Bendamustine hydrochloride for non-Hodgkin's lymphoma is 120 mg/m2 on days 1 and 2 of a 21-day cycle. The dose of Bendamustine hydrochloride may need to be adjusted based on a patient's individual needs and health status.
Conclusion:
Bendamustine hydrochloride is a chemotherapy drug that is used for the treatment of chronic lymphocytic leukemia (CLL) and non-Hodgkin's lymphoma. With its potent antitumor activity and other potential effects, Bendamustine hydrochloride has the potential to improve outcomes for cancer patients. It is important to understand the potential side effects of Bendamustine hydrochloride and to work closely with a healthcare provider to develop an appropriate treatment plan. While Bendamustine hydrochloride is generally well-tolerated, it is important to monitor for any signs of side effects or adverse reactions.
