BRL-15572 dihydrochloride is a selective antagonist of the neuropeptide Y5 receptor, a G-protein-coupled receptor that is primarily expressed in the brain. In this article, we will delve into the chemical properties of BRL-15572, its health benefits, potential effects, mechanism of action, possible side effects, and dosing information.
Chemical Properties
The chemical name of BRL-15572 dihydrochloride is (2S)-1-[2-[4-[(3,5-dichloro-2-methoxyphenyl)carbamoyl]phenyl]ethyl]-4-phenyl-4-oxobutanoic acid dihydrochloride. Its molecular formula is C28H25Cl2N2O5 and formula weight is 580.41 g/mol. The CAS number of BRL-15572 dihydrochloride is 193611-72-2.
Top Ten Keywords and Synonyms
Synonyms:
Health Benefits
BRL-15572 dihydrochloride has shown potential benefits in regulating appetite and reducing body weight in obesity. It may also have applications in treating type 2 diabetes and other metabolic disorders, as well as improving cardiovascular function and brain function.
Potential Effects
BRL-15572 dihydrochloride primarily acts as an antagonist of the neuropeptide Y5 receptor, which is involved in regulating appetite and energy balance in the brain. By blocking the neuropeptide Y5 receptor, BRL-15572 dihydrochloride can reduce appetite and food intake, leading to weight loss. Additionally, it may improve glucose metabolism and insulin sensitivity, contributing to the treatment of type 2 diabetes and other metabolic disorders. It has also been shown to improve cardiovascular function by reducing blood pressure and heart rate.
Product Mechanism
The neuropeptide Y5 receptor is a G-protein-coupled receptor that modulates the release of neuropeptide Y in the brain. Neuropeptide Y is involved in regulating appetite and energy balance, and blocking its signaling pathway can reduce food intake and promote weight loss. BRL-15572 dihydrochloride selectively binds to and blocks the neuropeptide Y5 receptor, thereby reducing its downstream signaling pathways and contributing to the reduction of food intake and weight loss.
Safety
BRL-15572 dihydrochloride has demonstrated a good safety profile in preclinical studies. However, there is limited information on its safety in humans, and further research is needed to determine its long-term safety and potential toxicities.
Side Effects
There is limited information on the side effects of BRL-15572 dihydrochloride in humans. In animal studies, it has been shown to cause mild sedation and changes in locomotor activity, but these effects are generally reversible and do not affect overall health or wellbeing.
Dosing Information
BRL-15572 dihydrochloride has been administered orally in preclinical studies at doses ranging from 0.1 to 30 mg/kg. The optimal dose and duration of treatment for various metabolic disorders are unknown, and further research is needed to establish safe and effective dosing regimens.
Conclusion
BRL-15572 dihydrochloride is a promising neuropeptide Y5 receptor antagonist with potential therapeutic applications in appetite regulation, weight loss, and metabolic disorders such as type 2 diabetes. Its mechanism of action involves reducing food intake and promoting weight loss by selectively blocking the neuropeptide Y5 receptor. While it has demonstrated a good safety profile in preclinical studies, more research is needed to determine its long-term safety and potential side effects in humans. Nonetheless, BRL-15572 dihydrochloride has great potential as a novel therapeutic agent in the treatment of various metabolic disorders.
