Flavopiridol hydrochloride, also known as Alvocidib, is a synthetic flavonoid derivative that acts as a broad-spectrum inhibitor of cyclin-dependent kinases (CDKs). It was first synthesized in 1994 by the researchers at Rhone-Poulenc Rorer (now Sanofi-Aventis), France. Flavopiridol hydrochloride has been studied extensively in clinical trials as a potential anticancer agent due to its ability to inhibit CDKs and induce apoptosis in cancer cells.
Chemical name: (R)-2-((2-(3-(1H-indol-3-yl)-4-(2-(hydroxymethyl)-1H-pyrrolo[3,2-c]pyridin-1-ylamino)pyrazolo[1,5-a]pyrimidin-7-yl)-1H-pyrrolo[2,3-d]pyrimidin-1-yl)amino)-1-phenylethan-1-ol hydrochloride Molecular formula: C29H30ClN7O2 Formula weight: 543.06 g/mol CAS No: 131740-09-5
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Synonyms: Alvocidib; Flavopiridol, hydrochloride; HMR-1275; L86-8275
Health Benefits of Flavopiridol Hydrochloride Flavopiridol hydrochloride is primarily used as a research tool and as a potential treatment for various cancers such as leukemia, lymphoma, and solid tumors.
Anti-tumor activity: Flavopiridol hydrochloride has been shown in preclinical studies to possess broad-spectrum anticancer activity by inhibiting the growth of various tumor cells.
Cancer cell apoptosis: Flavopiridol hydrochloride induces apoptosis in cancer cells by inhibiting CDKs, causing cell cycle arrest and decreasing the expression of anti-apoptotic proteins.
Cancer therapy: Flavopiridol hydrochloride has been tested in several clinical trials as a potential cancer therapy, both as monotherapy and in combination with other chemotherapeutic agents.
Potential Effects of Flavopiridol Hydrochloride
Induction of cell cycle arrest: Flavopiridol hydrochloride inhibits CDKs, preventing the cells from progressing through the cell cycle.
Induction of apoptosis: Flavopiridol hydrochloride induces apoptosis in cancer cells by activating the extrinsic and intrinsic apoptosis pathways.
Inhibition of transcription: Flavopiridol hydrochloride can inhibit the transcription of genes involved in cell growth and proliferation.
Product Mechanism Flavopiridol hydrochloride is a potent inhibitor of several CDKs, including CDK1, CDK2, CDK4, CDK6, and CDK7. CDKs are enzymes that regulate the cell cycle and control DNA replication and repair. Flavopiridol hydrochloride inhibits CDKs, causing cell cycle arrest and apoptosis in cancer cells. It has also been shown to inhibit transcriptional elongation by CDK9, which is involved in regulating the expression of various genes.
Safety Flavopiridol hydrochloride is a potent pharmaceutical agent and should be handled with care. It may cause some side effects in patients, as discussed below. It is recommended to follow the dosing guidelines and safety precautions when using this product.
Side Effects
Gastrointestinal disorders: Flavopiridol hydrochloride can cause nausea, vomiting, and diarrhea in some patients.
Hematological toxicity: Flavopiridol hydrochloride can cause hematological toxicity, including neutropenia, thrombocytopenia, and anemia.
Hepatotoxicity: Flavopiridol hydrochloride can cause liver damage and dysfunction, leading to hepatic toxicity.
Cardiovascular events: Flavopiridol hydrochloride can cause cardiovascular events, including arrhythmias and myocardial infarction.
Dosing Information Flavopiridol hydrochloride is administered intravenously at doses ranging from 30-100 mg/m². The optimal dose may vary depending on the specific cancer type and patient characteristics. It is recommended to follow the dosing guidelines provided by the supplier and to consult with a healthcare professional before using this product.
Conclusion Flavopiridol hydrochloride is a synthetic flavonoid derivative that acts as a broad-spectrum inhibitor of CDKs. It has shown promising results in preclinical studies as a potential anticancer agent due to its ability to induce apoptosis in cancer cells by inhibiting CDKs. Flavopiridol hydrochloride has been tested in clinical trials as a potential cancer therapy, both as monotherapy and in combination with other chemotherapeutic agents. While Flavopiridol hydrochloride is generally considered safe, it may cause some side effects and caution should be exercised when using this product.
