Fluticasone furoate (CAS: 397864-44-7) is a synthetic corticosteroid used for the treatment of respiratory conditions such as asthma and chronic obstructive pulmonary disease (COPD). Fluticasone furoate was first approved by the US Food and Drug Administration (FDA) under the brand name Arnuity Ellipta in 2014. This article will provide an overview of fluticasone furoate, including its chemical properties, health benefits, potential effects, product mechanism, safety, side effects, dosing information, and a conclusion on its use.
Chemical Properties The chemical name for fluticasone furoate is S-(fluoromethyl) 6α,9-difluoro-17-(2-furanyl)carbonyl)-11β-hydroxy-16α-methyl-3-oxoandrosta-1,4-diene-17β-carbothioate. Its molecular formula is C27H29F3O6S, and it has a formula weight of 538.58 g/mol. The CAS number for this compound is 397864-44-7.
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Health Benefits Fluticasone furoate is primarily used for the treatment of respiratory conditions such as asthma and COPD. It works by reducing inflammation in the airways and improving lung function. By decreasing inflammation, fluticasone furoate can help prevent asthma attacks and reduce symptoms associated with COPD.
Potential Effects In clinical trials, fluticasone furoate has been shown to be highly effective at improving lung function and reducing symptoms in patients with asthma and COPD. It has also been found to be well-tolerated, with few serious side effects reported. Additionally, fluticasone furoate has demonstrated good pharmacokinetic properties, meaning it is well-absorbed and distributed throughout the body, and is metabolized and eliminated from the body in a predictable manner.
Product Mechanism Fluticasone furoate is a synthetic corticosteroid that binds to the glucocorticoid receptor in the airway epithelium, resulting in decreased production and release of pro-inflammatory cytokines and chemokines. It also inhibits the activation and migration of inflammatory cells, leading to reduced inflammation in the airways. This effect leads to improved lung function and reduced symptoms in patients with respiratory diseases such as asthma and COPD.
Safety Overall, fluticasone furoate has been found to be safe and well-tolerated in clinical trials. However, like all medications, it does carry some risks of side effects and adverse events. Patients taking fluticasone furoate should be monitored regularly for any signs of allergic reactions, adrenal suppression, or other serious side effects.
Side Effects Some of the most common side effects reported with fluticasone furoate include headache, sore throat, and nasal congestion. These side effects are usually mild to moderate in severity and go away on their own over time. More serious side effects, such as osteoporosis or glaucoma, are rare but can occur in some patients.
Dosing Information Fluticasone furoate is typically administered via an inhaler or nasal spray. The recommended dose for patients with asthma is 100 mcg to 200 mcg once daily, while the recommended dose for patients with COPD is 100 mcg once daily. The dose may be adjusted based on individual patient needs and response.
Conclusion Fluticasone furoate is a highly effective and well-tolerated medication used for the treatment of respiratory conditions such as asthma and COPD. As a synthetic corticosteroid, it reduces inflammation in the airways and improves lung function, leading to reduced symptoms and fewer complications. While it does carry some risks of side effects and adverse events, overall, it has been found to be safe and effective in clinical trials. Patients taking fluticasone furoate should work closely with their healthcare providers to ensure proper dosing and monitoring for any potential side effects
