GSK1349572, also known as Dolutegravir, is a novel antiretroviral medication that has been developed for the treatment of HIV-1 infection. It was first approved by the US Food and Drug Administration (FDA) in 2013 and has since become a widely used medication for HIV treatment around the world. This article will provide an overview of GSK1349572/Dolutegravir, including its chemical properties, health benefits, potential effects, product mechanism, safety, side effects, dosing information, and a conclusion on its use.
Chemical Properties The chemical name of GSK1349572 is sodium [2R,5S]-2-[[(4-methyl-1,3-thiazol-5-yl)methyl]carbamoyl]-4-phenylbutanoate. Its molecular formula is C20H19N3NaO5S, and it has a formula weight of 441.43 g/mol. The CAS number for this compound is 10513375-16-6.
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Health Benefits GSK1349572 is primarily used to treat HIV-1 infection. It is an integrase inhibitor, which means it blocks the enzyme that is necessary for the virus to integrate its genetic material into the DNA of infected cells. By blocking this process, GSK1349572 can prevent the virus from replicating and spreading throughout the body. This can help to reduce viral load and improve immune function, thereby slowing or stopping the progression of the disease.
Potential Effects In clinical trials, GSK1349572 has been shown to be highly effective at reducing viral load and increasing CD4 cell counts in patients with HIV-1 infection. It has also been found to be well-tolerated, with few serious side effects reported. Additionally, GSK1349572 has demonstrated good pharmacokinetic properties, meaning it is well-absorbed and distributed throughout the body, and is metabolized and eliminated from the body in a predictable manner.
Product Mechanism GSK1349572 works by inhibiting the integrase enzyme, which is necessary for the replication of HIV-1. When the virus enters a host cell, it uses a reverse transcriptase enzyme to convert its RNA into DNA, which is then integrated into the host cell's genome by the integrase enzyme. By blocking this process, GSK1349572 prevents the virus from being able to replicate and spread throughout the body.
Safety Overall, GSK1349572 has been found to be safe and well-tolerated in clinical trials. However, like all medications, it does carry some risks of side effects and adverse events. Patients taking GSK1349572 should be monitored regularly for any signs of allergic reactions, liver dysfunction, or other serious side effects.
Side Effects Some of the most common side effects reported with GSK1349572 include nausea, diarrhea, headache, and fatigue. These side effects are usually mild to moderate in severity and go away on their own over time. More serious side effects, such as allergic reactions, liver dysfunction, or kidney failure, are rare but can occur in some patients.
Dosing Information GSK1349572 is typically taken once daily, either with or without food. The recommended dose for adults with HIV-1 infection is 50 mg per day. For patients with renal impairment or hepatic impairment, dosage adjustments may be necessary. Patients should follow their healthcare provider's instructions carefully when taking this medication.
Conclusion GSK1349572, also known as Dolutegravir, is a highly effective and well-tolerated antiretroviral medication that is used to treat HIV-1 infection. As an integrase inhibitor, it blocks the enzyme necessary for the virus to replicate and spread throughout the body. While it does carry some risks of side effects and adverse events, overall it has been found to be safe and effective in clinical trials. Patients taking GSK1349572 should work closely with their healthcare providers to ensure proper dosing and monitoring for any potential side effects or complications
