Nepicastat hydrochloride is a medication that is being investigated for the treatment of cocaine addiction and other related disorders. It belongs to the class of drugs known as selective norepinephrine reuptake inhibitors, which are used to treat a variety of psychiatric and neurological disorders. Nepicastat hydrochloride CAS: 170151-24-3 is a novel, potent and selective inhibitor of dopamine beta-hydroxylase (DBH), an enzyme that is involved in the biosynthesis of norepinephrine.
Chemical name: (S)-N-(2-aminoethyl)-6-[(2S)-2, 3-dihydro-1H-inden-2-yl]pyridazin-3-amine hydrochloride Molecular formula: C16H20N4•HCl Formula weight: 308.8 g/mol CAS No: 170151-24-3
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Synonyms: SYN-117; RS-25199-190; Nepicastat.
Health benefits of Nepicastat hydrochloride: Nepicastat hydrochloride is currently being investigated for the treatment of cocaine addiction and other related disorders. While its clinical use is still in the early stages of development, it has shown promise in preclinical studies as an effective treatment for cocaine addiction.
Potential effects: Nepicastat hydrochloride works by inhibiting the activity of the DBH enzyme, which is involved in the biosynthesis of norepinephrine. By blocking this enzyme, Nepicastat hydrochloride can reduce the level of norepinephrine in the brain, which can help reduce the cravings and withdrawal symptoms associated with cocaine addiction.
Product mechanism: Nepicastat hydrochloride works by selectively inhibiting the activity of the DBH enzyme, which is involved in the biosynthesis of norepinephrine. By blocking the activity of this enzyme, Nepicastat hydrochloride reduces the synthesis of norepinephrine, leading to reduced levels of the neurotransmitter in the brain. This mechanism of action has shown promise in preclinical studies as an effective treatment for cocaine addiction.
Safety: Since Nepicastat hydrochloride is still in the early stages of clinical development, there is limited information available regarding its safety profile. However, preclinical studies have shown that the drug may cause gastrointestinal disturbances, such as diarrhea and nausea.
Side effects: The most common side effects of Nepicastat hydrochloride observed in preclinical studies include gastrointestinal disturbances, such as diarrhea and nausea. Other adverse effects may include headache, vertigo, and dizziness.
Dosing information: Since Nepicastat hydrochloride is still in the early stages of clinical development, there is no established dosing information available. However, preclinical studies have shown that the drug is most effective at doses ranging from 10 to 100 mg/kg.
Conclusion: Nepicastat hydrochloride is a promising medication being investigated for the treatment of cocaine addiction and other related disorders. The drug works by selectively inhibiting the activity of the DBH enzyme, which is involved in the biosynthesis of norepinephrine, a neurotransmitter that plays a key role in the development and maintenance of cocaine addiction. While its clinical use is still in the early stages of development, preclinical studies have shown that Nepicastat hydrochloride has potential as an effective treatment for cocaine addiction, with a good safety profile. Researchers continue to investigate the potential benefits of Nepicastat hydrochloride in clinical trials and preclinical studies, with the hope that it may be useful in the treatment of various disorders related to norepinephrine dysregulation.
