Norethisterone enantate, CAS No. 3836-23-5, is a synthetic progestogen that is used in various hormonal contraceptives. It is a long-acting progestin that is administered through intramuscular injection. In this article, we will explore the chemical properties and health benefits of Norethisterone enantate and discuss its potential effects, mechanism of action, safety, side effects, and dosing information.
Norethisterone enantate has a chemical name of [(8R,9S,10R,13S,14S,17R)-17-acetyloxy-13-ethyl-3-oxo-1,2,6,7,8,9,10,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-17-yl] heptanoate, with a molecular formula of C27H38O4 and a formula weight of 430.59 g/mol.
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Norethisterone enantate is also known by several alternative names, including Norethinyl enanthate, Norlutin enanthate, and NETE. Other synonyms for this progestin include Norethindrone enantate and Norethandrolone enanthate.
Norethisterone enantate is primarily used as a contraceptive in various hormonal contraceptives. The progestin works by preventing ovulation, thickening cervical mucus, and altering the lining of the uterus, which reduces the likelihood of a fertilized egg implanting. Additionally, Norethisterone enantate can be used to treat menstrual disorders, including heavy bleeding, irregular periods, and painful periods.
The primary effect of Norethisterone enantate is its contraceptive ability. The progestin prevents ovulation, which reduces the likelihood of pregnancy. Additionally, Norethisterone enantate can reduce menstrual cramps, lighten periods, and improve menstrual regularity.
Norethisterone enantate works by altering the hormonal balance in the body to prevent ovulation. The progestin inhibits the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH), which are responsible for triggering ovulation. Additionally, Norethisterone enantate thickens cervical mucus, making it more difficult for sperm to reach the egg, and changes the lining of the uterus, which makes it less hospitable for implantation.
Norethisterone enantate is generally considered safe and effective when used as directed. However, like all medications, it is not without risks. Women who have a history of blood clots, stroke, or breast cancer may be at increased risk of complications from Norethisterone enantate use. Additionally, the progestin can increase the risk of cardiovascular events, including heart attack and stroke.
The use of Norethisterone enantate can result in several side effects, ranging from mild to severe. These include headache, nausea, bloating, breast tenderness, mood changes, weight gain, and irregular bleeding. Additionally, in rare cases, Norethisterone enantate can cause serious side effects, including blood clots, stroke, and liver damage.
Norethisterone enantate is administered through intramuscular injection, with a typical dosage of 200-400mg every 8-12 weeks. The injection should be given in the upper outer quadrant of the buttock, and the injection site should be rotated to reduce the risk of infection or tissue damage. Women who miss a scheduled injection may be at increased risk of pregnancy and should use alternate forms of contraception until they receive their next injection.
Norethisterone enantate is a long-acting progestin that is primarily used as a contraceptive in various hormonal contraceptives. The progestin works by preventing ovulation, thickening cervical mucus, and altering the lining of the uterus, which reduces the likelihood of a fertilized egg implanting. While generally considered safe and effective, Norethisterone enantate is not without risks and can cause several side effects. Users are advised to follow proper dosing guidelines and monitor their health status while using Norethisterone enantate. Additionally, women who have a history of blood clots, stroke, or breast cancer may be advised to use alternative forms of contraception.