Simeprevir sodium is a drug used to treat chronic hepatitis C virus (HCV) infection in adults. It belongs to a class of drugs known as direct-acting antivirals (DAAs).
Chemical name: The chemical name of Simeprevir sodium is (1R,5S,8S)-N-[(2S)-2-{(dimethylamino)carbonyl}-4-methylpentanoyl]-8-{[(3R)-1-(pyrrolidin-1-yl)carbonyl)-3,4-dihydroisoquinolin-2(1H)-yl]carbonyl}bicyclo[3.2.1]octane-2-carboxamide sodium salt.
Molecular formula: The molecular formula of Simeprevir sodium is C38H47N5NaO7.
Formula weight: The formula weight of Simeprevir sodium is 719.8 g/mol.
CAS No: The CAS No of Simeprevir sodium is 1241946-89-3.
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Health benefits of this product: Simeprevir sodium is used to treat chronic HCV infection, which can cause liver damage, cirrhosis, and liver cancer if left untreated. The drug works by inhibiting the NS3/4A protease enzyme, which is essential for HCV replication. By blocking this enzyme, Simeprevir sodium can reduce viral load and improve liver function. Studies have shown that the drug can achieve sustained virologic response (SVR) rates of up to 90% when used in combination with other DAAs such as sofosbuvir and ribavirin.
Potential effects: The use of Simeprevir sodium can lead to significant improvements in liver function and quality of life in patients with chronic HCV infection. In addition to reducing viral load and achieving SVR, the drug has been shown to decrease liver inflammation and fibrosis, risk of liver failure, and need for liver transplantation. Other potential effects of Simeprevir sodium include reduced transmission of HCV and improved survival rates.
Product mechanism: Simeprevir sodium works by inhibiting the NS3/4A protease enzyme, which is essential for HCV replication. The drug binds to the active site of the enzyme, preventing its activity and thereby reducing viral load. Simeprevir sodium is a selective inhibitor of NS3/4A protease and does not affect other proteases or host cell proteins.
Safety: Simeprevir sodium is generally safe and well-tolerated when used as directed. However, like all drugs, it can cause side effects in some patients. Common side effects of Simeprevir sodium include fatigue, headache, nausea, diarrhea, and rash. More serious side effects are rare but can include liver toxicity, allergic reactions, and skin disorders. Patients should be closely monitored for signs of adverse reactions while taking Simeprevir sodium.
Side effects: The most common side effects of Simeprevir sodium include fatigue, headache, nausea, diarrhea, and rash. These side effects usually resolve on their own and do not require medical attention. However, if they persist or become severe, patients should contact their healthcare provider. Less common but more serious side effects of Simeprevir sodium include liver toxicity, allergic reactions, and skin disorders. Patients who experience any of these symptoms should seek immediate medical attention.
Dosing information: Simeprevir sodium is available in capsules of 150 mg strength. The recommended dose is one capsule taken orally once daily with food. The drug should be used in combination with other antiviral agents such as sofosbuvir and ribavirin, as directed by a healthcare provider. The duration of treatment varies depending on the patient's genotype and treatment history.
Conclusion: Simeprevir sodium is a direct-acting antiviral drug used to treat chronic hepatitis C virus infection in adults. The drug works by inhibiting the NS3/4A protease enzyme, which is essential for HCV replication. Simeprevir sodium has been shown to achieve high rates of sustained virologic response and improve liver function and quality of life in patients with chronic HCV infection
