Unveiling Tafluprost Ethyl Amide: A Comparative Analysis
Tafluprost ethyl amide, with the molecular formula C24H33F2NO4, is a derivative of 17-phenyl trinor Prostaglandin F2α (17-phenyl trinor PGF2α) and an analog of the prostaglandin F2alpha (PGF2alpha) receptor agonist tafluprost. This compound has garnered interest due to its potential in reducing intraocular pressure (IOP) and influencing eyelash growth, hence finding use in antiglaucoma ophthalmic compositions or cosmetics. Tafluprost ethyl amide also tends to increase lipid solubility, thereby improving uptake into tissues and further lowering the effective concentration.
Top Ten Keywords and Synonyms:
Some of the relevant keywords associated with Tafluprost ethyl amide include Corey lactone, Julia–Lythgoe olefination, fluorination, prostaglandins, and tafluprost, which are tied to its synthesis and application. Additionally, technical terms like N-ethyl-9α,11α-dihydroxy-15,15-difluoro-16-phenoxy-17,18,19,20-tetranor-prosta-5Z,13E-dien-1-amide are pertinent in understanding its molecular structure.
Competitive products primarily consist of those containing tafluprost or similar prostaglandin analogs. Products like Zioptan (tafluprost ophthalmic) in the United States and Taflotan or Saflutan in Europe are used as ophthalmic glaucoma agents. Furthermore, Sigma-Aldrich mentions similar products available alongside Tafluprost ethyl amide, however, the specifics of these products weren't provided.
Various contraindications and side effects are associated with the use of Tafluprost ethyl amide. Pregnant and breastfeeding women are advised against its use due to the potential of affecting the child. Moreover, it should be used under the supervision of an ophthalmologist to prevent eye and ophthalmic defects11. Other effects include changes in eye color, eyelash growth, and potentially local irritant side effects, especially in products aiming to reduce intraocular pressure
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