WAY-100635 maleate is a selective serotonin 5-HT1A receptor antagonist that has been extensively studied in neuroscience research as a tool for exploring serotonin function and its role in various psychiatric disorders. This article will provide an overview of WAY-100635 maleate, including its chemical properties, health benefits, potential effects, product mechanism, safety considerations, side effects, dosing information, and conclusions.
Introduce this product:
WAY-100635 maleate is a synthetic compound that selectively binds to the serotonin 5-HT1A receptor with high affinity and specificity. This receptor subtype is widely distributed throughout the brain and is involved in many physiological processes, including mood regulation, anxiety, cognition, and sleep. By blocking the 5-HT1A receptor, WAY-100635 maleate can modulate serotonin signaling and produce various effects on behavior and physiology.
Chemical name:
N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide maleate
Molecular formula:
C27H36N4O2.C4H4O4
Formula weight:
624.7 g/mol
CAS No:
1092679-51-0
Top ten keywords from Google and synonyms:
Synonyms:
WAY-100635 (maleate salt), N-[(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl]-N-(2-pyridinyl)cyclohexanecarboxamide maleate salt
Health benefits of this product:
WAY-100635 maleate has several potential health benefits, particularly in the field of neuroscience research. It has been used as a tool for investigating the role of serotonin 5-HT1A receptors in various neuropsychiatric disorders, such as depression, anxiety, schizophrenia, and autism spectrum disorders. Moreover, it has been suggested as a non-invasive biomarker for assessing 5-HT1A receptor binding in vivo using positron emission tomography (PET) imaging.
Potential effects:
The potential effects of WAY-100635 maleate depend on its target, the serotonin 5-HT1A receptor, which has complex and diverse functions in the brain and peripheral tissues. By blocking this receptor, WAY-100635 maleate can alter the activity of multiple neural circuits and systems, leading to various behavioral and physiological effects, including:
Antidepressant effects: 5-HT1A receptor agonists have been shown to produce antidepressant-like effects in preclinical and clinical studies, and their blockade by WAY-100635 maleate may reverse these effects. This suggests that 5-HT1A receptor dysfunction may contribute to the pathophysiology of depression.
Anxiolytic effects: Similarly, 5-HT1A receptor agonists have been found to reduce anxiety-like behaviors in animal models and humans, and their blockade by WAY-100635 maleate may enhance anxiety.
Modulation of autonomic functions: 5-HT1A receptors are also involved in regulating autonomic functions, such as blood pressure, heart rate, and gastrointestinal motility, and their blockade by WAY-100635 maleate can affect these parameters.
Cognitive effects: 5-HT1A receptors have been implicated in cognitive processes, such as memory, attention, and learning, and their blockade by WAY-100635 maleate may impair these functions.
Product mechanism:
WAY-100635 maleate acts as a competitive antagonist at the serotonin 5-HT1A receptor, preventing its activation by endogenous serotonin or exogenous agonists. The 5-HT1A receptor is a G protein-coupled receptor that inhibits adenylate cyclase and reduces intracellular cAMP levels upon activation. By blocking this pathway, WAY-100635 maleate can prevent downstream signaling and produce its effects on behavior and physiology.
Safety:
WAY-100635 maleate is generally considered safe and well-tolerated when used in research settings. However, like any drug, it has potential side effects and safety concerns that should be taken into account. Some of the reported adverse effects include dizziness, nausea, headache, and fatigue. Moreover, since the 5-HT1A receptor is widely distributed throughout the body, the blockade of this receptor may lead to off-target effects on other organs or systems.
Side effects:
The most common side effects associated with the use of WAY-100635 maleate in research studies include mild to moderate dizziness
